TSN19_HUMAN
ID TSN19_HUMAN Reviewed; 248 AA.
AC P0C672;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Tetraspanin-19 {ECO:0000305};
DE Short=Tspan-19;
GN Name=TSPAN19 {ECO:0000312|HGNC:HGNC:31886};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC025418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44949.1; -.
DR RefSeq; NP_001094387.1; NM_001100917.1.
DR RefSeq; XP_005268726.1; XM_005268669.4.
DR RefSeq; XP_016874351.1; XM_017018862.1.
DR AlphaFoldDB; P0C672; -.
DR SMR; P0C672; -.
DR STRING; 9606.ENSP00000433816; -.
DR GlyGen; P0C672; 2 sites.
DR iPTMnet; P0C672; -.
DR PhosphoSitePlus; P0C672; -.
DR BioMuta; TSPAN19; -.
DR DMDM; 166991177; -.
DR PaxDb; P0C672; -.
DR PRIDE; P0C672; -.
DR ProteomicsDB; 52324; -.
DR Antibodypedia; 70744; 4 antibodies from 4 providers.
DR DNASU; 144448; -.
DR Ensembl; ENST00000532498.7; ENSP00000433816.2; ENSG00000231738.11.
DR GeneID; 144448; -.
DR KEGG; hsa:144448; -.
DR MANE-Select; ENST00000532498.7; ENSP00000433816.2; NM_001100917.2; NP_001094387.1.
DR UCSC; uc009zsj.4; human.
DR CTD; 144448; -.
DR GeneCards; TSPAN19; -.
DR HGNC; HGNC:31886; TSPAN19.
DR HPA; ENSG00000231738; Tissue enhanced (retina, testis).
DR neXtProt; NX_P0C672; -.
DR OpenTargets; ENSG00000231738; -.
DR PharmGKB; PA142670689; -.
DR VEuPathDB; HostDB:ENSG00000231738; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000163725; -.
DR HOGENOM; CLU_055524_4_1_1; -.
DR InParanoid; P0C672; -.
DR OMA; WVFGVQV; -.
DR OrthoDB; 1170714at2759; -.
DR PhylomeDB; P0C672; -.
DR TreeFam; TF316345; -.
DR PathwayCommons; P0C672; -.
DR SignaLink; P0C672; -.
DR BioGRID-ORCS; 144448; 12 hits in 1030 CRISPR screens.
DR ChiTaRS; TSPAN19; human.
DR GenomeRNAi; 144448; -.
DR Pharos; P0C672; Tdark.
DR PRO; PR:P0C672; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P0C672; protein.
DR Bgee; ENSG00000231738; Expressed in olfactory segment of nasal mucosa and 87 other tissues.
DR ExpressionAtlas; P0C672; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..248
FT /note="Tetraspanin-19"
FT /id="PRO_0000317254"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 248 AA; 28460 MW; E15FE8E971987382 CRC64;
MLRNNKTIII KYFLNLINGA FLVLGLLFMG FGAWLLLDRN NFLTAFDENN HFIVPISQIL
IGMGSSTVLF CLLGYIGIHN EIRWLLIVYA VLITWTFAVQ VVLSAFIITK KEEVQQLWHD
KIDFVISEYG SKDKPEDITK WTILNALQKT LQCCGQHNYT DWIKNKNKEN SGQVPCSCTK
STLRKWFCDE PLNATYLEGC ENKISAWYNV NVLTLIGINF GLLTSEVFQV SLTVCFFKNI
KNIIHAEM
