ID   TSN1_BOVIN              Reviewed;         241 AA.
AC   Q3T0S3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Tetraspanin-1;
DE            Short=Tspan-1;
GN   Name=TSPAN1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC102280; AAI02281.1; -; mRNA.
DR   RefSeq; NP_001029442.1; NM_001034270.1.
DR   AlphaFoldDB; Q3T0S3; -.
DR   SMR; Q3T0S3; -.
DR   STRING; 9913.ENSBTAP00000017715; -.
DR   PaxDb; Q3T0S3; -.
DR   Ensembl; ENSBTAT00000017715; ENSBTAP00000017715; ENSBTAG00000013320.
DR   GeneID; 506550; -.
DR   KEGG; bta:506550; -.
DR   CTD; 10103; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013320; -.
DR   VGNC; VGNC:36425; TSPAN1.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000158851; -.
DR   HOGENOM; CLU_055524_4_1_1; -.
DR   InParanoid; Q3T0S3; -.
DR   OMA; HKESKCL; -.
DR   OrthoDB; 1406848at2759; -.
DR   TreeFam; TF352892; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000013320; Expressed in abomasum and 78 other tissues.
DR   GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..241
FT                   /note="Tetraspanin-1"
FT                   /id="PRO_0000247132"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..52
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        141
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        154
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   241 AA;  26208 MW;  FB1D7902F95B8D5F CRC64;
     MGCFNFIKVM MILFNMLIFL CGAALLAVGI WVSVDGPSFV KIFGPMSSSA MQFVNVGYFL
     IAAGAVLFAL GFLGCYGAQT ESKCALMTFF FILLLIFIAE VAAAVVALVY TTLAENFLTA
     VVVPNIKKEY GSQKDFTQVW NSTMAGLKCC GFTNYTDFEG SPYVRKNGTF PPYCCYDSVN
     NSFMEPCNNF TAHNMSVQGC FKQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL
     E