TSN1_MOUSE
ID TSN1_MOUSE Reviewed; 240 AA.
AC Q99J59; A6PW93;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Tetraspanin-1;
DE Short=Tspan-1;
GN Name=Tspan1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAO78026.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAO78128.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK078869; BAC37431.1; -; mRNA.
DR EMBL; CH466552; EDL30614.1; -; Genomic_DNA.
DR EMBL; AL670603; CAM19375.1; -; Genomic_DNA.
DR EMBL; AL611947; CAM19375.1; JOINED; Genomic_DNA.
DR EMBL; AL611947; CAM20669.1; -; Genomic_DNA.
DR EMBL; AL670603; CAM20669.1; JOINED; Genomic_DNA.
DR EMBL; AL670603; CAO78026.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL611947; CAO78026.1; JOINED; Genomic_DNA.
DR EMBL; AL611947; CAO78128.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL670603; CAO78128.1; JOINED; Genomic_DNA.
DR EMBL; BC003448; AAH03448.1; -; mRNA.
DR CCDS; CCDS18508.1; -.
DR RefSeq; NP_598442.1; NM_133681.4.
DR RefSeq; XP_006503353.1; XM_006503290.2.
DR AlphaFoldDB; Q99J59; -.
DR SMR; Q99J59; -.
DR STRING; 10090.ENSMUSP00000030465; -.
DR GlyGen; Q99J59; 1 site.
DR PhosphoSitePlus; Q99J59; -.
DR PaxDb; Q99J59; -.
DR PRIDE; Q99J59; -.
DR Antibodypedia; 32752; 278 antibodies from 31 providers.
DR DNASU; 66805; -.
DR Ensembl; ENSMUST00000030465; ENSMUSP00000030465; ENSMUSG00000028699.
DR GeneID; 66805; -.
DR KEGG; mmu:66805; -.
DR UCSC; uc008ugk.1; mouse.
DR CTD; 10103; -.
DR MGI; MGI:1914055; Tspan1.
DR VEuPathDB; HostDB:ENSMUSG00000028699; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000158851; -.
DR HOGENOM; CLU_055524_4_1_1; -.
DR InParanoid; Q99J59; -.
DR OMA; HKESKCL; -.
DR OrthoDB; 1406848at2759; -.
DR PhylomeDB; Q99J59; -.
DR TreeFam; TF352892; -.
DR BioGRID-ORCS; 66805; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tspan1; mouse.
DR PRO; PR:Q99J59; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q99J59; protein.
DR Bgee; ENSMUSG00000028699; Expressed in left colon and 88 other tissues.
DR ExpressionAtlas; Q99J59; baseline and differential.
DR Genevisible; Q99J59; MM.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0031982; C:vesicle; ISO:MGI.
DR GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..240
FT /note="Tetraspanin-1"
FT /id="PRO_0000382891"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 240 AA; 26356 MW; AD4C448A32BC2999 CRC64;
MQCFKFIKVM MFLFNLLIFL CGAALLAVGI WVSVDGTSFL KVFGSLSSSA MQFVNVGYFL
IAAGAVLFIL GFLGCYGAHS ENKCVLMMFF SILLIIFIAE IAGAVVALVY TTLAEQFLTL
LVVPAIEKDY GYQTDFTQVW NTTMEELHCC GFNNYTDFNA SRFVKENKVF PPPCCANPGN
HTVEPCTEEK AKSMKVQGCF KEILHRIRAN AVTVGGVAVG VAALELAAMV VSMYLYCNLK
