TSN31_HUMAN
ID TSN31_HUMAN Reviewed; 210 AA.
AC Q12999; O00577; Q53X76;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Tetraspanin-31;
DE Short=Tspan-31;
DE AltName: Full=Sarcoma-amplified sequence;
GN Name=TSPAN31; Synonyms=SAS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Osteosarcoma;
RX PubMed=8134123;
RA Jankowski S.A., Mitchell D.S., Smith S.H., Trent J.M., Meltzer P.S.;
RT "SAS, a gene amplified in human sarcomas, encodes a new member of the
RT transmembrane 4 superfamily of proteins.";
RL Oncogene 9:1205-1211(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9192850; DOI=10.1006/geno.1997.4727;
RA Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A.,
RA Meltzer P.S.;
RT "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3
RT amplification in human cancers.";
RL Genomics 42:295-301(1997).
RN [3]
RP SEQUENCE REVISION TO 76-77 AND 205-210.
RA Roe B.A.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q12999; O95393: BMP10; NbExp=3; IntAct=EBI-17678331, EBI-3922513;
CC Q12999; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-17678331, EBI-11522780;
CC Q12999; P78329: CYP4F2; NbExp=3; IntAct=EBI-17678331, EBI-1752413;
CC Q12999; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-17678331, EBI-2863634;
CC Q12999; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-17678331, EBI-8644112;
CC Q12999; O60636: TSPAN2; NbExp=3; IntAct=EBI-17678331, EBI-3914288;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; U01160; AAA17782.1; -; mRNA.
DR EMBL; U81031; AAC39524.2; -; Genomic_DNA.
DR EMBL; AK315765; BAG38117.1; -; mRNA.
DR EMBL; CR407647; CAG28575.1; -; mRNA.
DR EMBL; CH471054; EAW97057.1; -; Genomic_DNA.
DR EMBL; BC010377; AAH10377.1; -; mRNA.
DR CCDS; CCDS8952.1; -.
DR PIR; I58391; I58391.
DR RefSeq; NP_001317097.1; NM_001330168.1.
DR RefSeq; NP_001317098.1; NM_001330169.1.
DR RefSeq; NP_005972.1; NM_005981.4.
DR AlphaFoldDB; Q12999; -.
DR SMR; Q12999; -.
DR BioGRID; 112209; 60.
DR IntAct; Q12999; 6.
DR STRING; 9606.ENSP00000257910; -.
DR GlyGen; Q12999; 4 sites.
DR iPTMnet; Q12999; -.
DR PhosphoSitePlus; Q12999; -.
DR SwissPalm; Q12999; -.
DR BioMuta; TSPAN31; -.
DR DMDM; 6174973; -.
DR EPD; Q12999; -.
DR jPOST; Q12999; -.
DR MassIVE; Q12999; -.
DR PaxDb; Q12999; -.
DR PeptideAtlas; Q12999; -.
DR PRIDE; Q12999; -.
DR ProteomicsDB; 59088; -.
DR Antibodypedia; 28904; 131 antibodies from 25 providers.
DR DNASU; 6302; -.
DR Ensembl; ENST00000257910.8; ENSP00000257910.3; ENSG00000135452.10.
DR GeneID; 6302; -.
DR KEGG; hsa:6302; -.
DR MANE-Select; ENST00000257910.8; ENSP00000257910.3; NM_005981.5; NP_005972.1.
DR UCSC; uc001spt.4; human.
DR CTD; 6302; -.
DR DisGeNET; 6302; -.
DR GeneCards; TSPAN31; -.
DR HGNC; HGNC:10539; TSPAN31.
DR HPA; ENSG00000135452; Low tissue specificity.
DR MIM; 181035; gene.
DR neXtProt; NX_Q12999; -.
DR OpenTargets; ENSG00000135452; -.
DR PharmGKB; PA34949; -.
DR VEuPathDB; HostDB:ENSG00000135452; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000160351; -.
DR HOGENOM; CLU_088363_0_0_1; -.
DR InParanoid; Q12999; -.
DR OMA; WGILENN; -.
DR OrthoDB; 1203231at2759; -.
DR PhylomeDB; Q12999; -.
DR TreeFam; TF323367; -.
DR PathwayCommons; Q12999; -.
DR SignaLink; Q12999; -.
DR BioGRID-ORCS; 6302; 36 hits in 1077 CRISPR screens.
DR ChiTaRS; TSPAN31; human.
DR GeneWiki; TSPAN31; -.
DR GenomeRNAi; 6302; -.
DR Pharos; Q12999; Tbio.
DR PRO; PR:Q12999; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q12999; protein.
DR Bgee; ENSG00000135452; Expressed in pancreatic ductal cell and 205 other tissues.
DR ExpressionAtlas; Q12999; baseline and differential.
DR Genevisible; Q12999; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..210
FT /note="Tetraspanin-31"
FT /id="PRO_0000219270"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 210 AA; 23053 MW; 8A1FF8CC5319755E CRC64;
MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI AVGVFLLLIA
VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN RSKQTDVINA SWWVMSNKTR
DELERSFDCC GLFNLTTLYQ QDYDFCTAIC KSQSPTCQMC GEKFLKHSDE ALKILGGVGL
FFSFTEILGV WLAMRFRNQK DPRANPSAFL
