TSN36_DANRE
ID TSN36_DANRE Reviewed; 243 AA.
AC Q6NWG0; Q6DGE3;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Tetraspanin-36 {ECO:0000312|ZFIN:ZDB-GENE-040718-248};
DE AltName: Full=Tetraspanin-3c {ECO:0000303|PubMed:24734316};
GN Name=tspan36 {ECO:0000312|ZFIN:ZDB-GENE-040718-248};
GN Synonyms=tspan3c {ECO:0000303|PubMed:24734316};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000312|EMBL:AAH76407.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore; TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, AND
RP MUTAGENESIS OF ILE-18.
RX PubMed=24734316; DOI=10.1111/pcmr.12192;
RA Inoue S., Kondo S., Parichy D.M., Watanabe M.;
RT "Tetraspanin 3c requirement for pigment cell interactions and boundary
RT formation in zebrafish adult pigment stripes.";
RL Pigment Cell Melanoma Res. 27:190-200(2014).
CC -!- FUNCTION: Plays a role in migration and segregation of pigment cells
CC (melanophores and xanthophores). Contributes to pigment stripe
CC patterning in the epidermis. {ECO:0000269|PubMed:24734316}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:24734316}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:24734316}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Mainly found in the Golgi apparatus.
CC {ECO:0000269|PubMed:24734316}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in melanophores and
CC xanthophores. Also detected in eye, brain, heart, skin, fin, testis and
CC ovary. {ECO:0000269|PubMed:24734316}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:24734316}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000255,
CC ECO:0000255|RuleBase:RU361218}.
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DR EMBL; AL928845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT956087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067604; AAH67604.2; -; mRNA.
DR EMBL; BC076407; AAH76407.1; -; mRNA.
DR RefSeq; NP_001002748.1; NM_001002748.2.
DR AlphaFoldDB; Q6NWG0; -.
DR SMR; Q6NWG0; -.
DR STRING; 7955.ENSDARP00000032359; -.
DR PaxDb; Q6NWG0; -.
DR Ensembl; ENSDART00000032498; ENSDARP00000032359; ENSDARG00000024540.
DR Ensembl; ENSDART00000189986; ENSDARP00000151391; ENSDARG00000109488.
DR GeneID; 437021; -.
DR KEGG; dre:437021; -.
DR CTD; 437021; -.
DR ZFIN; ZDB-GENE-040718-248; tspan36.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000164634; -.
DR HOGENOM; CLU_055524_5_2_1; -.
DR InParanoid; Q6NWG0; -.
DR OMA; LRESKCG; -.
DR OrthoDB; 1467737at2759; -.
DR PhylomeDB; Q6NWG0; -.
DR TreeFam; TF316345; -.
DR PRO; PR:Q6NWG0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000024540; Expressed in spleen and 30 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043473; P:pigmentation; IMP:ZFIN.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Endoplasmic reticulum; Glycoprotein;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..243
FT /note="Tetraspanin-36"
FT /id="PRO_0000442536"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..49
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..208
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT MUTAGEN 18
FT /note="I->R: In dali; retained in the endoplasmic
FT reticulum. Incomplete N-glycosylation. Defective migration
FT and cell-cell interaction between melanophores and
FT xanthophores, leading to abnormal pigment stripe
FT patterning."
FT /evidence="ECO:0000269|PubMed:24734316"
SQ SEQUENCE 243 AA; 26885 MW; F8499A0C77C94ADF CRC64;
MDCGIITSKT ILLLLSLIFW AAGAALAYVG SYVIKSYNNF EDFMSDRHTL IPAAIIIGVA
VVMFIIGFVG CCATLRESKV GLGLFLIIIM LIFAAEVTAF VFGIIYRGRI RGDLEKSMND
VFLKYDGLNS ETHAVDYLQS QLECCGVKNQ TDWTLTSWFA QHNNTVPQSC CKANMTQCTG
QLSQPDLLNT QGCEAKLEQV LQDVLSYAML VILGFAIIKF FGMLSVCVIT CKSKKNEYQP
LYA
