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TSN5_BOVIN
ID   TSN5_BOVIN              Reviewed;         268 AA.
AC   Q17QJ5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Tetraspanin-5;
DE            Short=Tspan-5;
GN   Name=TSPAN5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH ADAM10.
RX   PubMed=23035126; DOI=10.1074/jbc.m112.416503;
RA   Haining E.J., Yang J., Bailey R.L., Khan K., Collier R., Tsai S.,
RA   Watson S.P., Frampton J., Garcia P., Tomlinson M.G.;
RT   "The TspanC8 subgroup of tetraspanins interacts with A disintegrin and
RT   metalloprotease 10 (ADAM10) and regulates its maturation and cell surface
RT   expression.";
RL   J. Biol. Chem. 287:39753-39765(2012).
CC   -!- FUNCTION: Regulates ADAM10 maturation and trafficking to the cell
CC       surface. Promotes ADAM10-mediated cleavage of CD44.
CC       {ECO:0000250|UniProtKB:P62079, ECO:0000250|UniProtKB:P62080}.
CC   -!- SUBUNIT: Interacts with ADAM10. {ECO:0000269|PubMed:23035126}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62079};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC118327; AAI18328.1; -; mRNA.
DR   RefSeq; NP_001069587.1; NM_001076119.1.
DR   AlphaFoldDB; Q17QJ5; -.
DR   SMR; Q17QJ5; -.
DR   STRING; 9913.ENSBTAP00000016375; -.
DR   PaxDb; Q17QJ5; -.
DR   PRIDE; Q17QJ5; -.
DR   Ensembl; ENSBTAT00000016375; ENSBTAP00000016375; ENSBTAG00000012343.
DR   GeneID; 538668; -.
DR   KEGG; bta:538668; -.
DR   CTD; 10098; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012343; -.
DR   VGNC; VGNC:36440; TSPAN5.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000161376; -.
DR   HOGENOM; CLU_055524_0_2_1; -.
DR   InParanoid; Q17QJ5; -.
DR   OMA; RECAWDE; -.
DR   OrthoDB; 1180379at2759; -.
DR   TreeFam; TF313002; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000012343; Expressed in semen and 102 other tissues.
DR   ExpressionAtlas; Q17QJ5; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..268
FT                   /note="Tetraspanin-5"
FT                   /id="PRO_0000287713"
FT   TOPO_DOM        1..17
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..61
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..232
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..268
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        174
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        232
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   268 AA;  30307 MW;  6A4480BD0BB7083C CRC64;
     MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG IAFLGIGLWA WNEKGVLSNI SSITDLGGFD
     PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK
     DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC
     GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF
     IGIALLQIFG ICLAQNLVSD IEAVRASW
 
 
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