TSN5_BOVIN
ID TSN5_BOVIN Reviewed; 268 AA.
AC Q17QJ5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Tetraspanin-5;
DE Short=Tspan-5;
GN Name=TSPAN5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP INTERACTION WITH ADAM10.
RX PubMed=23035126; DOI=10.1074/jbc.m112.416503;
RA Haining E.J., Yang J., Bailey R.L., Khan K., Collier R., Tsai S.,
RA Watson S.P., Frampton J., Garcia P., Tomlinson M.G.;
RT "The TspanC8 subgroup of tetraspanins interacts with A disintegrin and
RT metalloprotease 10 (ADAM10) and regulates its maturation and cell surface
RT expression.";
RL J. Biol. Chem. 287:39753-39765(2012).
CC -!- FUNCTION: Regulates ADAM10 maturation and trafficking to the cell
CC surface. Promotes ADAM10-mediated cleavage of CD44.
CC {ECO:0000250|UniProtKB:P62079, ECO:0000250|UniProtKB:P62080}.
CC -!- SUBUNIT: Interacts with ADAM10. {ECO:0000269|PubMed:23035126}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62079};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; BC118327; AAI18328.1; -; mRNA.
DR RefSeq; NP_001069587.1; NM_001076119.1.
DR AlphaFoldDB; Q17QJ5; -.
DR SMR; Q17QJ5; -.
DR STRING; 9913.ENSBTAP00000016375; -.
DR PaxDb; Q17QJ5; -.
DR PRIDE; Q17QJ5; -.
DR Ensembl; ENSBTAT00000016375; ENSBTAP00000016375; ENSBTAG00000012343.
DR GeneID; 538668; -.
DR KEGG; bta:538668; -.
DR CTD; 10098; -.
DR VEuPathDB; HostDB:ENSBTAG00000012343; -.
DR VGNC; VGNC:36440; TSPAN5.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161376; -.
DR HOGENOM; CLU_055524_0_2_1; -.
DR InParanoid; Q17QJ5; -.
DR OMA; RECAWDE; -.
DR OrthoDB; 1180379at2759; -.
DR TreeFam; TF313002; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000012343; Expressed in semen and 102 other tissues.
DR ExpressionAtlas; Q17QJ5; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..268
FT /note="Tetraspanin-5"
FT /id="PRO_0000287713"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 268 AA; 30307 MW; 6A4480BD0BB7083C CRC64;
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG IAFLGIGLWA WNEKGVLSNI SSITDLGGFD
PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK
DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC
GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF
IGIALLQIFG ICLAQNLVSD IEAVRASW