TSN5_HUMAN
ID TSN5_HUMAN Reviewed; 268 AA.
AC P62079; B2RDY2; O60628; O60746; Q6FHE5; Q9JLY1;
DT 21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Tetraspanin-5;
DE Short=Tspan-5;
DE AltName: Full=Tetraspan NET-4;
DE AltName: Full=Transmembrane 4 superfamily member 9;
GN Name=TSPAN5; Synonyms=TM4SF9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9714763; DOI=10.1016/s0167-4781(98)00087-6;
RA Todd S.C., Doctor V.S., Levy S.;
RT "Sequences and expression of six new members of the tetraspanin/TM4SF
RT family.";
RL Biochim. Biophys. Acta 1399:101-104(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Rubinstein E., Serru V., Boucheix C.;
RT "New tetraspans identified in the EST database.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, INTERACTION WITH ADAM10, AND SUBCELLULAR LOCATION.
RX PubMed=26686862; DOI=10.1007/s00018-015-2111-z;
RA Jouannet S., Saint-Pol J., Fernandez L., Nguyen V., Charrin S.,
RA Boucheix C., Brou C., Milhiet P.E., Rubinstein E.;
RT "TspanC8 tetraspanins differentially regulate the cleavage of ADAM10
RT substrates, Notch activation and ADAM10 membrane compartmentalization.";
RL Cell. Mol. Life Sci. 73:1895-1915(2016).
CC -!- FUNCTION: Regulates ADAM10 maturation and trafficking to the cell
CC surface. Promotes ADAM10-mediated cleavage of CD44.
CC {ECO:0000269|PubMed:26686862}.
CC -!- SUBUNIT: Interacts with ADAM10. {ECO:0000269|PubMed:26686862}.
CC -!- INTERACTION:
CC P62079; O14672: ADAM10; NbExp=11; IntAct=EBI-20977525, EBI-1536151;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AF053455; AAC69712.1; -; Genomic_DNA.
DR EMBL; AF065389; AAC17120.1; -; mRNA.
DR EMBL; CR541809; CAG46608.1; -; mRNA.
DR EMBL; AK315723; BAG38079.1; -; mRNA.
DR EMBL; CH471057; EAX06074.1; -; Genomic_DNA.
DR EMBL; BC009704; AAH09704.1; -; mRNA.
DR CCDS; CCDS3646.1; -.
DR PIR; A59261; A59261.
DR RefSeq; NP_005714.2; NM_005723.3.
DR AlphaFoldDB; P62079; -.
DR SMR; P62079; -.
DR BioGRID; 115405; 82.
DR IntAct; P62079; 81.
DR STRING; 9606.ENSP00000307701; -.
DR GlyGen; P62079; 4 sites.
DR iPTMnet; P62079; -.
DR PhosphoSitePlus; P62079; -.
DR SwissPalm; P62079; -.
DR BioMuta; TSPAN5; -.
DR DMDM; 49065848; -.
DR jPOST; P62079; -.
DR MassIVE; P62079; -.
DR MaxQB; P62079; -.
DR PaxDb; P62079; -.
DR PeptideAtlas; P62079; -.
DR PRIDE; P62079; -.
DR ProteomicsDB; 57363; -.
DR Antibodypedia; 25821; 184 antibodies from 27 providers.
DR DNASU; 10098; -.
DR Ensembl; ENST00000305798.8; ENSP00000307701.3; ENSG00000168785.8.
DR GeneID; 10098; -.
DR KEGG; hsa:10098; -.
DR MANE-Select; ENST00000305798.8; ENSP00000307701.3; NM_005723.4; NP_005714.2.
DR UCSC; uc003hub.4; human.
DR CTD; 10098; -.
DR DisGeNET; 10098; -.
DR GeneCards; TSPAN5; -.
DR HGNC; HGNC:17753; TSPAN5.
DR HPA; ENSG00000168785; Tissue enhanced (brain).
DR MIM; 613136; gene.
DR neXtProt; NX_P62079; -.
DR OpenTargets; ENSG00000168785; -.
DR PharmGKB; PA134864098; -.
DR VEuPathDB; HostDB:ENSG00000168785; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161376; -.
DR HOGENOM; CLU_055524_0_2_1; -.
DR InParanoid; P62079; -.
DR OMA; RECAWDE; -.
DR OrthoDB; 1180379at2759; -.
DR PhylomeDB; P62079; -.
DR TreeFam; TF313002; -.
DR PathwayCommons; P62079; -.
DR Reactome; R-HSA-977225; Amyloid fiber formation.
DR SignaLink; P62079; -.
DR BioGRID-ORCS; 10098; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; TSPAN5; human.
DR GenomeRNAi; 10098; -.
DR Pharos; P62079; Tbio.
DR PRO; PR:P62079; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P62079; protein.
DR Bgee; ENSG00000168785; Expressed in secondary oocyte and 190 other tissues.
DR ExpressionAtlas; P62079; baseline and differential.
DR Genevisible; P62079; HS.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; IMP:UniProtKB.
DR GO; GO:0051604; P:protein maturation; IMP:UniProtKB.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..268
FT /note="Tetraspanin-5"
FT /id="PRO_0000219243"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 91..94
FT /note="Missing (in Ref. 1; AAC69712)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 30337 MW; 7F4480BD0FA6192D CRC64;
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI SSITDLGGFD
PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK
DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC
GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF
IGIALLQIFG ICLAQNLVSD IEAVRASW
