TSN5_MOUSE
ID TSN5_MOUSE Reviewed; 268 AA.
AC P62080; O60628; O60746; Q9JLY1;
DT 21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Tetraspanin-5;
DE Short=Tspan-5;
DE AltName: Full=Tetraspan NET-4;
DE AltName: Full=Transmembrane 4 superfamily member 9;
GN Name=Tspan5; Synonyms=Tm4sf9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster / NIH;
RA Garcia-Frigola C., de Lecea L., Soriano E.;
RT "Mouse Tspan-5 cDNA cloning.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH ADAM10.
RX PubMed=23035126; DOI=10.1074/jbc.m112.416503;
RA Haining E.J., Yang J., Bailey R.L., Khan K., Collier R., Tsai S.,
RA Watson S.P., Frampton J., Garcia P., Tomlinson M.G.;
RT "The TspanC8 subgroup of tetraspanins interacts with A disintegrin and
RT metalloprotease 10 (ADAM10) and regulates its maturation and cell surface
RT expression.";
RL J. Biol. Chem. 287:39753-39765(2012).
RN [4]
RP INTERACTION WITH ADAM10.
RX PubMed=26668317; DOI=10.1074/jbc.m115.703058;
RA Noy P.J., Yang J., Reyat J.S., Matthews A.L., Charlton A.E., Furmston J.,
RA Rogers D.A., Rainger G.E., Tomlinson M.G.;
RT "TspanC8 tetraspanins and A disintegrin and metalloprotease 10 (ADAM10)
RT interact via their extracellular regions: evidence for distinct binding
RT mechanisms for different TspanC8 proteins.";
RL J. Biol. Chem. 291:3145-3157(2016).
CC -!- FUNCTION: Regulates ADAM10 maturation and trafficking to the cell
CC surface (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44
CC (By similarity). {ECO:0000250|UniProtKB:P62079,
CC ECO:0000269|PubMed:23035126}.
CC -!- SUBUNIT: Interacts with ADAM10. {ECO:0000269|PubMed:23035126,
CC ECO:0000269|PubMed:26668317}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62079};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AF121344; AAF28869.1; -; mRNA.
DR EMBL; BC058695; AAH58695.1; -; mRNA.
DR CCDS; CCDS17870.1; -.
DR RefSeq; NP_062517.1; NM_019571.5.
DR AlphaFoldDB; P62080; -.
DR SMR; P62080; -.
DR STRING; 10090.ENSMUSP00000029800; -.
DR GlyGen; P62080; 4 sites.
DR PhosphoSitePlus; P62080; -.
DR SwissPalm; P62080; -.
DR MaxQB; P62080; -.
DR PaxDb; P62080; -.
DR PRIDE; P62080; -.
DR ProteomicsDB; 297994; -.
DR Antibodypedia; 25821; 184 antibodies from 27 providers.
DR DNASU; 56224; -.
DR Ensembl; ENSMUST00000029800; ENSMUSP00000029800; ENSMUSG00000028152.
DR GeneID; 56224; -.
DR KEGG; mmu:56224; -.
DR UCSC; uc008rnp.2; mouse.
DR CTD; 10098; -.
DR MGI; MGI:1928096; Tspan5.
DR VEuPathDB; HostDB:ENSMUSG00000028152; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161376; -.
DR HOGENOM; CLU_055524_0_2_1; -.
DR InParanoid; P62080; -.
DR OMA; RECAWDE; -.
DR OrthoDB; 1180379at2759; -.
DR PhylomeDB; P62080; -.
DR TreeFam; TF313002; -.
DR BioGRID-ORCS; 56224; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Tspan5; mouse.
DR PRO; PR:P62080; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P62080; protein.
DR Bgee; ENSMUSG00000028152; Expressed in olfactory bulb mitral cell layer and 273 other tissues.
DR ExpressionAtlas; P62080; baseline and differential.
DR Genevisible; P62080; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISO:MGI.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
DR GO; GO:0051604; P:protein maturation; IDA:UniProtKB.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..268
FT /note="Tetraspanin-5"
FT /id="PRO_0000219244"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 30
FT /note="G -> E (in Ref. 2; AAH58695)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 30337 MW; 7F4480BD0FA6192D CRC64;
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI SSITDLGGFD
PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK
DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC
GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF
IGIALLQIFG ICLAQNLVSD IEAVRASW
