ID   TSN6_BOVIN              Reviewed;         245 AA.
AC   Q32KU6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Tetraspanin-6;
DE            Short=Tspan-6;
GN   Name=TSPAN6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC109924; AAI09925.1; -; mRNA.
DR   RefSeq; NP_001033198.1; NM_001038109.1.
DR   RefSeq; XP_005227812.1; XM_005227755.3.
DR   RefSeq; XP_010819934.1; XM_010821632.2.
DR   AlphaFoldDB; Q32KU6; -.
DR   SMR; Q32KU6; -.
DR   STRING; 9913.ENSBTAP00000056037; -.
DR   PaxDb; Q32KU6; -.
DR   PRIDE; Q32KU6; -.
DR   Ensembl; ENSBTAT00000063874; ENSBTAP00000056037; ENSBTAG00000045550.
DR   Ensembl; ENSBTAT00000074307; ENSBTAP00000064048; ENSBTAG00000045550.
DR   Ensembl; ENSBTAT00000086776; ENSBTAP00000060038; ENSBTAG00000045550.
DR   GeneID; 514741; -.
DR   KEGG; bta:514741; -.
DR   CTD; 7105; -.
DR   VEuPathDB; HostDB:ENSBTAG00000045550; -.
DR   VGNC; VGNC:36441; TSPAN6.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000159092; -.
DR   HOGENOM; CLU_055524_3_0_1; -.
DR   InParanoid; Q32KU6; -.
DR   OMA; WEKTEYF; -.
DR   OrthoDB; 1145558at2759; -.
DR   TreeFam; TF352891; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000045550; Expressed in semen and 106 other tissues.
DR   ExpressionAtlas; Q32KU6; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1901223; P:negative regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0039532; P:negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..245
FT                   /note="Tetraspanin-6"
FT                   /id="PRO_0000247133"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..245
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   245 AA;  27524 MW;  232603E6AA7C5646 CRC64;
     MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF SLLNEKATNV
     PFVLIGTGTV IILLGTFGCF ATCRASAWML KLYAMFLTLI FLVELVAAII GFVFRHEIKN
     SLKNNYEKAL KQYNATGDYR SDAVDKIQSM LHCCGVTNYR DWKDTNYYSE KGFPESCCKL
     EDCSPQRDAD KVNNEGCFIM VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN
     QYEIV