ID   TSN6_MOUSE              Reviewed;         245 AA.
AC   O70401;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Tetraspanin-6;
DE            Short=Tspan-6;
DE   AltName: Full=Transmembrane 4 superfamily member 6;
GN   Name=Tspan6; Synonyms=Tm4sf6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9714763; DOI=10.1016/s0167-4781(98)00087-6;
RA   Todd S.C., Doctor V.S., Levy S.;
RT   "Sequences and expression of six new members of the tetraspanin/TM4SF
RT   family.";
RL   Biochim. Biophys. Acta 1399:101-104(1998).
RN   [2]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-134.
RX   PubMed=19349973; DOI=10.1038/nbt.1532;
RA   Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA   Schiess R., Aebersold R., Watts J.D.;
RT   "Mass-spectrometric identification and relative quantification of N-linked
RT   cell surface glycoproteins.";
RL   Nat. Biotechnol. 27:378-386(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; AF053454; AAC69711.1; -; mRNA.
DR   CCDS; CCDS30387.1; -.
DR   PIR; A59260; A59260.
DR   AlphaFoldDB; O70401; -.
DR   SMR; O70401; -.
DR   STRING; 10090.ENSMUSP00000084838; -.
DR   GlyGen; O70401; 1 site.
DR   iPTMnet; O70401; -.
DR   SwissPalm; O70401; -.
DR   MaxQB; O70401; -.
DR   PaxDb; O70401; -.
DR   PeptideAtlas; O70401; -.
DR   PRIDE; O70401; -.
DR   ProteomicsDB; 297725; -.
DR   MGI; MGI:1926264; Tspan6.
DR   eggNOG; KOG3882; Eukaryota.
DR   InParanoid; O70401; -.
DR   ChiTaRS; Tspan6; mouse.
DR   PRO; PR:O70401; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O70401; protein.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1901223; P:negative regulation of NIK/NF-kappaB signaling; ISO:MGI.
DR   GO; GO:0039532; P:negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; ISO:MGI.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..245
FT                   /note="Tetraspanin-6"
FT                   /id="PRO_0000219247"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..245
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19349973"
SQ   SEQUENCE   245 AA;  27333 MW;  25F68411E3602A12 CRC64;
     MASPSRRLQT KPVITCLKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF SLLNEKATNV
     PFVLIGTGTV IILLGTFGCF ATCRTSAWML KLYAMFLTLI FLVELVAAIV GFVFRHEIKN
     SFKSNYENAL KEYNSTGDYR SEAVDKIQST LHCCGVTNYG DWKGTNYYSE TGFPKSCCKL
     EGCYPQRDAD KVNEEGCFIK VMTTIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN
     QYEIV