TSN7_MOUSE
ID TSN7_MOUSE Reviewed; 249 AA.
AC Q62283; O88429; Q9DBS3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Tetraspanin-7;
DE Short=Tspan-7;
DE AltName: Full=Cell surface glycoprotein A15;
DE AltName: Full=PE31;
DE AltName: Full=TALLA homolog;
DE AltName: Full=Transmembrane 4 superfamily member 2;
DE AltName: CD_antigen=CD231;
GN Name=Tspan7; Synonyms=Mxs1, Tm4sf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
RC STRAIN=BALB/cJ; TISSUE=Brain;
RA Nagira M., Ishikawa K., Fujikawa K., Takagi S., Yoshie O.;
RT "Molecular cloning and expression of mouse PE31 (TALLA).";
RL Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=10617319; DOI=10.1016/s0168-0102(99)00093-0;
RA Hosokawa Y., Ueyama E., Morikawa Y., Maeda Y., Seto M., Senba E.;
RT "Molecular cloning of a cDNA encoding mouse A15, a member of the
RT transmembrane 4 superfamily, and its preferential expression in brain
RT neurons.";
RL Neurosci. Res. 35:281-290(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in cell proliferation and cell motility.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC34579.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA05493.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D26483; BAA05493.1; ALT_INIT; mRNA.
DR EMBL; AF052492; AAC34579.1; ALT_INIT; mRNA.
DR EMBL; AK004776; BAB23554.1; -; mRNA.
DR CCDS; CCDS30016.1; -.
DR RefSeq; NP_062608.2; NM_019634.2.
DR AlphaFoldDB; Q62283; -.
DR SMR; Q62283; -.
DR BioGRID; 204231; 1.
DR STRING; 10090.ENSMUSP00000075692; -.
DR GlyGen; Q62283; 5 sites.
DR PhosphoSitePlus; Q62283; -.
DR SwissPalm; Q62283; -.
DR jPOST; Q62283; -.
DR MaxQB; Q62283; -.
DR PaxDb; Q62283; -.
DR PeptideAtlas; Q62283; -.
DR PRIDE; Q62283; -.
DR ProteomicsDB; 297995; -.
DR DNASU; 21912; -.
DR Ensembl; ENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
DR GeneID; 21912; -.
DR KEGG; mmu:21912; -.
DR UCSC; uc009sqm.1; mouse.
DR CTD; 7102; -.
DR MGI; MGI:1298407; Tspan7.
DR VEuPathDB; HostDB:ENSMUSG00000058254; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000156153; -.
DR HOGENOM; CLU_055524_3_0_1; -.
DR InParanoid; Q62283; -.
DR OMA; NWNTSPY; -.
DR OrthoDB; 1145558at2759; -.
DR PhylomeDB; Q62283; -.
DR TreeFam; TF352891; -.
DR Reactome; R-MMU-416993; Trafficking of GluR2-containing AMPA receptors.
DR BioGRID-ORCS; 21912; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tspan7; mouse.
DR PRO; PR:Q62283; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q62283; protein.
DR Bgee; ENSMUSG00000058254; Expressed in dentate gyrus of hippocampal formation granule cell and 261 other tissues.
DR ExpressionAtlas; Q62283; baseline and differential.
DR Genevisible; Q62283; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..249
FT /note="Tetraspanin-7"
FT /id="PRO_0000219249"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 146
FT /note="R -> P (in Ref. 2; AAC34579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27544 MW; 04B3A24D16B5DCD3 CRC64;
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY
VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF
LRTYTDAMQN YNGNDERSRA VDHVQRSLSC CGVQNYTNWS SSPYFLDHGI PPSCCMNETD
CNPLDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF
ITANQYEMV
