ID   TSN8_BOVIN              Reviewed;         238 AA.
AC   Q2KIS9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Tetraspanin-8;
DE            Short=Tspan-8;
GN   Name=TSPAN8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC112523; AAI12524.1; -; mRNA.
DR   RefSeq; NP_001073097.1; NM_001079629.2.
DR   AlphaFoldDB; Q2KIS9; -.
DR   SMR; Q2KIS9; -.
DR   STRING; 9913.ENSBTAP00000025875; -.
DR   PaxDb; Q2KIS9; -.
DR   GeneID; 617508; -.
DR   KEGG; bta:617508; -.
DR   CTD; 7103; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   InParanoid; Q2KIS9; -.
DR   OrthoDB; 1205716at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..238
FT                   /note="Tetraspanin-8"
FT                   /id="PRO_0000284963"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..57
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..206
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  26208 MW;  9B8BB87A636641C2 CRC64;
     MAGVNVCIKC SMFIFNFVFW LCGAIILSVA ISIRAGKIGQ EILAPGDADL NLFIAVNILI
     FVGAVIMILG FLGCCGAMKE NQFMMILFFV GLLMILLLQV AAGIVATTRK SKTEQALNKT
     LLINARLLSS TDENERVFQK AFSELQEELK CCGLVNGASD WGSNFQHYYR TCECPSESDS
     SCTKYSGKTI YKQSCFASIS QMFSKRLFIV LALAFGLAAI EVLGLIFSIV LYCQMRKK