TSN8_MOUSE
ID TSN8_MOUSE Reviewed; 235 AA.
AC Q8R3G9;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Tetraspanin-8;
DE Short=Tspan-8;
GN Name=Tspan8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AC126270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC153364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466539; EDL21777.1; -; Genomic_DNA.
DR EMBL; CH466539; EDL21778.1; -; Genomic_DNA.
DR EMBL; CH466539; EDL21779.1; -; Genomic_DNA.
DR EMBL; CH466539; EDL21780.1; -; Genomic_DNA.
DR EMBL; BC025461; AAH25461.1; -; mRNA.
DR EMBL; BC027777; AAH27777.1; -; mRNA.
DR EMBL; BC029068; AAH29068.1; -; mRNA.
DR EMBL; BC029808; AAH29808.1; -; mRNA.
DR EMBL; BC034198; AAH34198.1; -; mRNA.
DR CCDS; CCDS24181.1; -.
DR RefSeq; NP_001162150.1; NM_001168679.1.
DR RefSeq; NP_001162151.1; NM_001168680.1.
DR RefSeq; NP_666122.1; NM_146010.2.
DR RefSeq; XP_006513605.1; XM_006513542.2.
DR AlphaFoldDB; Q8R3G9; -.
DR SMR; Q8R3G9; -.
DR IntAct; Q8R3G9; 1.
DR STRING; 10090.ENSMUSP00000049243; -.
DR GlyGen; Q8R3G9; 1 site.
DR iPTMnet; Q8R3G9; -.
DR PhosphoSitePlus; Q8R3G9; -.
DR jPOST; Q8R3G9; -.
DR MaxQB; Q8R3G9; -.
DR PaxDb; Q8R3G9; -.
DR PeptideAtlas; Q8R3G9; -.
DR PRIDE; Q8R3G9; -.
DR ProteomicsDB; 297726; -.
DR Antibodypedia; 29509; 314 antibodies from 37 providers.
DR DNASU; 216350; -.
DR Ensembl; ENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127.
DR Ensembl; ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127.
DR Ensembl; ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127.
DR GeneID; 216350; -.
DR KEGG; mmu:216350; -.
DR UCSC; uc007hbm.2; mouse.
DR CTD; 7103; -.
DR MGI; MGI:2384918; Tspan8.
DR VEuPathDB; HostDB:ENSMUSG00000034127; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000158153; -.
DR HOGENOM; CLU_055524_4_2_1; -.
DR InParanoid; Q8R3G9; -.
DR OMA; GCLKYSM; -.
DR OrthoDB; 1205716at2759; -.
DR PhylomeDB; Q8R3G9; -.
DR TreeFam; TF352895; -.
DR BioGRID-ORCS; 216350; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tspan8; mouse.
DR PRO; PR:Q8R3G9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8R3G9; protein.
DR Bgee; ENSMUSG00000034127; Expressed in seminal vesicle and 161 other tissues.
DR ExpressionAtlas; Q8R3G9; baseline and differential.
DR Genevisible; Q8R3G9; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; ISO:MGI.
DR GO; GO:0030195; P:negative regulation of blood coagulation; ISO:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
DR GO; GO:0007283; P:spermatogenesis; IDA:MGI.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..235
FT /note="Tetraspanin-8"
FT /id="PRO_0000415811"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 235 AA; 25582 MW; 1660D73299D7B2EB CRC64;
MAGVSSCLKY SMFFFNFLFW VCGTLILGLA IWVRVSKDGK EIITSGDSST NPFIAVNILI
AVGSIIMVLG FLGCCGAVKE SRCMLLLFFI GLLLILILQV AAGILGAAFK PEYNRILNET
LYENAKLLSD NTDEAKDFQK AMIVFQSEFK CCGLENGAAD WGNNFVEAKE SCQCTGTDCA
TYQGSSVYPK TCLSLIKDLF EKNIIIVIGI AFGLAVIEIL GLVFSMVLYC QIGSK
