ID   TSN_CHICK               Reviewed;         229 AA.
AC   P79769;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Translin;
DE            EC=3.1.-.-;
DE   AltName: Full=Component 3 of promoter of RISC;
DE            Short=C3PO;
GN   Name=TSN;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thymus;
RA   Kasai M.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DNA/RNA-BINDING REGION.
RX   PubMed=10025964; DOI=10.1016/s0014-5793(99)00010-1;
RA   Aoki K., Suzuki K., Ishida R., Kasai M.;
RT   "The DNA binding activity of Translin is mediated by a basic region in the
RT   ring-shaped structure conserved in evolution.";
RL   FEBS Lett. 443:363-366(1999).
CC   -!- FUNCTION: DNA-binding protein that specifically recognizes consensus
CC       sequences at the breakpoint junctions in chromosomal translocations,
CC       mostly involving immunoglobulin (Ig)/T-cell receptor gene segments.
CC       Seems to recognize single-stranded DNA ends generated by staggered
CC       breaks occurring at recombination hot spots (By similarity).
CC       {ECO:0000250}.
CC   -!- FUNCTION: Exhibits both single-stranded and double-stranded
CC       endoribonuclease activity. May act as an activator of RNA-induced
CC       silencing complex (RISC) by facilitating endonucleolytic cleavage of
CC       the siRNA passenger strand (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Ring-shaped heterooctamer of six TSN and two TSNAX subunits,
CC       DNA/RNA binding occurs inside the ring. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the translin family. {ECO:0000305}.
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DR   EMBL; X95074; CAA64470.1; -; mRNA.
DR   RefSeq; NP_990404.1; NM_205073.1.
DR   AlphaFoldDB; P79769; -.
DR   SMR; P79769; -.
DR   STRING; 9031.ENSGALP00000019018; -.
DR   PaxDb; P79769; -.
DR   GeneID; 395955; -.
DR   KEGG; gga:395955; -.
DR   CTD; 7247; -.
DR   VEuPathDB; HostDB:geneid_395955; -.
DR   eggNOG; KOG3067; Eukaryota.
DR   InParanoid; P79769; -.
DR   OrthoDB; 1187354at2759; -.
DR   PhylomeDB; P79769; -.
DR   PRO; PR:P79769; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0016070; P:RNA metabolic process; IEA:InterPro.
DR   CDD; cd14819; Translin; 1.
DR   Gene3D; 1.20.58.190; -; 1.
DR   Gene3D; 1.20.58.200; -; 1.
DR   InterPro; IPR033956; Translin.
DR   InterPro; IPR016069; Translin_C.
DR   InterPro; IPR002848; Translin_fam.
DR   InterPro; IPR016068; Translin_N.
DR   InterPro; IPR036081; Translin_sf.
DR   PANTHER; PTHR10741; PTHR10741; 1.
DR   PANTHER; PTHR10741:SF2; PTHR10741:SF2; 1.
DR   Pfam; PF01997; Translin; 1.
DR   SUPFAM; SSF74784; SSF74784; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Endonuclease; Hydrolase; Nuclease; Nucleus;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..229
FT                   /note="Translin"
FT                   /id="PRO_0000191685"
FT   REGION          86..90
FT                   /note="DNA/RNA binding"
FT   REGION          177..198
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   229 AA;  25961 MW;  E1DB50693A84D2C9 CRC64;
     MSVSAMFVAL QGALTADQDI REEIRKVVQA LEQTAREMLT LPQGVHQGAG FQDIPKKCQK
     AREHFGTVRT QMESLKTKFP ADQYYRFHEH WRFVLQRLVF LASFVVYLET ETLVTREAVA
     EILGIEADRE RGFHLDIEDY LSGVLTLASE LARLAVNSVT AGDYSRPLRI STFINELDSG
     FRLLNLKNDS LRKRYDGLKY DVKKIEEVVY DLSIRGLNKE ATGGAGGEK