TSP17_CAEEL
ID TSP17_CAEEL Reviewed; 312 AA.
AC Q11098; A0A0K3AT70; A0A0K3AW84; A0A0K3AYG5; B3WFU6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2019, sequence version 4.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Tetraspanin-17 {ECO:0000303|PubMed:25474638};
GN Name=tsp-17 {ECO:0000303|PubMed:25474638, ECO:0000312|WormBase:C02F12.1b};
GN ORFNames=C02F12.1 {ECO:0000312|WormBase:C02F12.1b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF GLY-109.
RX PubMed=25474638; DOI=10.1371/journal.pgen.1004767;
RA Masoudi N., Ibanez-Cruceyra P., Offenburger S.L., Holmes A., Gartner A.;
RT "Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced
RT neurodegeneration in C. elegans.";
RL PLoS Genet. 10:E1004767-E1004767(2014).
RN [3]
RP FUNCTION.
RX PubMed=29346364; DOI=10.1371/journal.pgen.1007106;
RA Offenburger S.L., Jongsma E., Gartner A.;
RT "Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis
RT pathway and the calcium chaperone crt-1 increase dopaminergic
RT neurodegeneration after 6-OHDA treatment.";
RL PLoS Genet. 14:E1007106-E1007106(2018).
CC -!- FUNCTION: Protects dopaminergic neurons against oxidative stress-
CC induced neurodegeneration (PubMed:25474638, PubMed:29346364). May act
CC partly via dopamine receptor dop-2 to negatively regulate dopamine
CC reuptake transporter dat-1 activity (PubMed:25474638). Also plays a
CC role in modulating behaviors linked to dopamine signaling
CC (PubMed:25474638). Confers protection against oxidative stress in the
CC whole body (PubMed:29346364). {ECO:0000269|PubMed:25474638,
CC ECO:0000269|PubMed:29346364}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:25474638};
CC Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite
CC {ECO:0000305|PubMed:25474638}. Cell projection, axon
CC {ECO:0000305|PubMed:25474638}. Note=May localize near the nucleus or
CC ER. {ECO:0000305|PubMed:25474638}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=b {ECO:0000312|WormBase:C02F12.1a}; Synonyms=Long
CC {ECO:0000303|PubMed:25474638};
CC IsoId=Q11098-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:C02F12.1a};
CC IsoId=Q11098-2; Sequence=VSP_060366;
CC Name=c {ECO:0000312|WormBase:C02F12.1c};
CC IsoId=Q11098-3; Sequence=VSP_060367;
CC Name=d {ECO:0000312|WormBase:C02F12.1d};
CC IsoId=Q11098-4; Sequence=VSP_060365, VSP_060367;
CC Name=e {ECO:0000312|WormBase:C02F12.1e};
CC IsoId=Q11098-5; Sequence=VSP_060365;
CC -!- TISSUE SPECIFICITY: Expressed in dopaminergic neurons, head muscles,
CC vulva and spermatheca. {ECO:0000269|PubMed:25474638}.
CC -!- DEVELOPMENTAL STAGE: In larvae, expressed in the NSM serotonergic
CC neuron and in muscles. {ECO:0000269|PubMed:25474638}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; BX284606; CCD62373.1; -; Genomic_DNA.
DR EMBL; BX284606; CCD62379.1; -; Genomic_DNA.
DR EMBL; BX284606; CTQ87024.1; -; Genomic_DNA.
DR EMBL; BX284606; CTQ87025.1; -; Genomic_DNA.
DR EMBL; BX284606; CTQ87026.1; -; Genomic_DNA.
DR RefSeq; NP_001129920.2; NM_001136448.2. [Q11098-1]
DR RefSeq; NP_001300313.1; NM_001313384.1. [Q11098-3]
DR RefSeq; NP_001300314.1; NM_001313385.1. [Q11098-4]
DR RefSeq; NP_001300315.1; NM_001313386.1. [Q11098-5]
DR RefSeq; NP_508634.3; NM_076233.3.
DR AlphaFoldDB; Q11098; -.
DR BioGRID; 56559; 1.
DR STRING; 6239.C02F12.1b; -.
DR EnsemblMetazoa; C02F12.1a.1; C02F12.1a.1; WBGene00006643. [Q11098-2]
DR EnsemblMetazoa; C02F12.1b.1; C02F12.1b.1; WBGene00006643. [Q11098-1]
DR EnsemblMetazoa; C02F12.1c.1; C02F12.1c.1; WBGene00006643. [Q11098-3]
DR EnsemblMetazoa; C02F12.1d.1; C02F12.1d.1; WBGene00006643. [Q11098-4]
DR EnsemblMetazoa; C02F12.1e.1; C02F12.1e.1; WBGene00006643. [Q11098-5]
DR GeneID; 192067; -.
DR KEGG; cel:CELE_C02F12.1; -.
DR UCSC; C02F12.1; c. elegans. [Q11098-1]
DR CTD; 192067; -.
DR WormBase; C02F12.1a; CE50471; WBGene00006643; tsp-17. [Q11098-2]
DR WormBase; C02F12.1b; CE45957; WBGene00006643; tsp-17. [Q11098-1]
DR WormBase; C02F12.1c; CE50481; WBGene00006643; tsp-17. [Q11098-3]
DR WormBase; C02F12.1d; CE50466; WBGene00006643; tsp-17. [Q11098-4]
DR WormBase; C02F12.1e; CE50399; WBGene00006643; tsp-17. [Q11098-5]
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000173612; -.
DR HOGENOM; CLU_055524_4_2_1; -.
DR InParanoid; Q11098; -.
DR OMA; FWYITNT; -.
DR OrthoDB; 1051357at2759; -.
DR PhylomeDB; Q11098; -.
DR PRO; PR:Q11098; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006643; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0030425; C:dendrite; IDA:WormBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR GO; GO:0031749; F:D2 dopamine receptor binding; IPI:WormBase.
DR GO; GO:0072756; P:cellular response to paraquat; IMP:UniProtKB.
DR GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IMP:UniProtKB.
DR GO; GO:1902883; P:negative regulation of response to oxidative stress; IMP:UniProtKB.
DR GO; GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IMP:UniProtKB.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cell projection; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Tetraspanin-17"
FT /id="PRO_0000219294"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..123
FT /note="Missing (in isoform d and isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_060365"
FT VAR_SEQ 119..152
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_060366"
FT VAR_SEQ 150..259
FT /note="QFYVYSVKENVREIVKSKYGVMTSEPENKMVTEFIDKLQFYEKCCGSLGPTD
FT YISSRWSQSTNQDSEEIESPLFPVSCCTQITGASALNPLAKSYARCQQIGANRQWRHA
FT -> QFYHQCCGGEGPLDYKDSFWYITNTLRGTRSFVPPSCCKQAQVGRAWAPVPIDPMC
FT TTYRYLTTAFDTSVNT (in isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_060367"
FT MUTAGEN 109
FT /note="G->E: In gt1681; in larvae, enhances
FT neurodegeneration of dopaminergic neurons induced by the
FT oxidative stress agent 6-hydroxydopamine (6-OHDA).
FT Hypersensitivity to 6-OHDA is abolished in a dat-1 (ok157)
FT mutant background and partially reduced in a dop-2 or dop-3
FT mutant background. Reduces dopamine reuptake by transporter
FT dat-1. Loss of cell membrane localization."
FT /evidence="ECO:0000269|PubMed:25474638"
FT MUTAGEN 109
FT /note="G->R: In vc2026; enhances neurodegeneration of
FT dopaminergic neurons induced by the oxidative stress agent
FT 6-hydroxydopamine (6-OHDA)."
FT /evidence="ECO:0000269|PubMed:25474638"
SQ SEQUENCE 312 AA; 35478 MW; 6D171F2243F1F2C6 CRC64;
MATERDGGGC LRVAVSIFSI YYWLSALGHV FLGLWMLLDP KRNYILDLVH FSENDPLLKA
SAYVSLVCGC AQLLVGFLGL CGAVNRSRFL LLAFVMFLIG TFLADVAMGT LSLFYKDKFS
NNYMGVYLKN LTYNRYSRDR WVLPLMDTIQ FYVYSVKENV REIVKSKYGV MTSEPENKMV
TEFIDKLQFY EKCCGSLGPT DYISSRWSQS TNQDSEEIES PLFPVSCCTQ ITGASALNPL
AKSYARCQQI GANRQWRHAV GCSERLMSWF NEQIWIFVGF GFGSALTMML GICLSCCLIS
KIRIYHVIRD DY
