TSP1_CAEEL
ID TSP1_CAEEL Reviewed; 244 AA.
AC P34285;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Tetraspanin-1;
GN Name=tsp-1; ORFNames=C02F5.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; FO080288; CCD62634.1; -; Genomic_DNA.
DR PIR; S44610; S44610.
DR RefSeq; NP_498804.1; NM_066403.4.
DR AlphaFoldDB; P34285; -.
DR SMR; P34285; -.
DR STRING; 6239.C02F5.8; -.
DR EPD; P34285; -.
DR PaxDb; P34285; -.
DR PeptideAtlas; P34285; -.
DR EnsemblMetazoa; C02F5.8.1; C02F5.8.1; WBGene00006627.
DR GeneID; 192096; -.
DR KEGG; cel:CELE_C02F5.8; -.
DR UCSC; C02F5.8; c. elegans.
DR CTD; 192096; -.
DR WormBase; C02F5.8; CE00044; WBGene00006627; tsp-1.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000165843; -.
DR HOGENOM; CLU_099570_0_0_1; -.
DR InParanoid; P34285; -.
DR OMA; FNIRVWL; -.
DR OrthoDB; 1341599at2759; -.
DR PhylomeDB; P34285; -.
DR Reactome; R-CEL-446107; Type I hemidesmosome assembly.
DR PRO; PR:P34285; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006627; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="Tetraspanin-1"
FT /id="PRO_0000219293"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 27428 MW; 19CFBBCB9EE3EB29 CRC64;
MATWKFIIRS VLFFLDLAML LAALALIAVG FWMGYDSSFD TDLKNVIYKY DDPKSLADAK
FNIRVWLIVV FWSIIGLSLG AVVTAVLGMI SSVWPKRKGF MITYLVLIIV LVSLEIGCGV
AVLVRRNSLH DNTNSLIDAM YTTNSVNDLK IIQDKYNCCG IENSLFNVMY CGPMSQKPHC
DVAVFDSVDN TMMISGIILL VILILQTIAI ILPVPILISR KKTYKYSYEP RVTQLADITE
DTRF
