ID   TSPOB_HUMAN             Reviewed;         102 AA.
AC   B1AH88; Q13849; Q6IAZ7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Putative peripheral benzodiazepine receptor-related protein;
GN   Name=TSPO; Synonyms=PBRS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ARG-53.
RC   TISSUE=Placenta;
RX   PubMed=8307574; DOI=10.1016/s0888-7543(05)80367-2;
RA   Lin D., Chang Y.J., Strauss J.F., Miller W.L.;
RT   "The human peripheral benzodiazepine receptor gene: cloning and
RT   characterization of alternative splicing in normal tissues and in a patient
RT   with congenital lipoid adrenal hyperplasia.";
RL   Genomics 18:643-650(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-53.
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-53.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2; Synonyms=PBR-S;
CC         IsoId=B1AH88-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=P30536-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- MISCELLANEOUS: [Isoform 2]: The relatively low levels of the
CC       corresponding mRNA suggest that it might represent errors of the
CC       splicing machinery. In addition, isoform 2 is derived from a different
CC       reading frame, compared to isoform 1 and lacks homolog support.
CC   -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
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DR   EMBL; L21950; AAA18227.1; -; mRNA.
DR   EMBL; CR457007; CAG33288.1; -; mRNA.
DR   EMBL; Z82214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471138; EAW73290.1; -; Genomic_DNA.
DR   PIR; A49361; A49361.
DR   AlphaFoldDB; B1AH88; -.
DR   BindingDB; B1AH88; -.
DR   BioMuta; TSPO; -.
DR   PRIDE; B1AH88; -.
DR   Antibodypedia; 27480; 290 antibodies from 40 providers.
DR   DNASU; 706; -.
DR   GeneCards; TSPO; -.
DR   HGNC; HGNC:1158; TSPO.
DR   HPA; ENSG00000100300; Tissue enhanced (esophagus).
DR   neXtProt; NX_B1AH88; -.
DR   PharmGKB; PA25473; -.
DR   VEuPathDB; HostDB:ENSG00000100300; -.
DR   PathwayCommons; B1AH88; -.
DR   ChiTaRS; TSPO; human.
DR   Pharos; B1AH88; Tchem.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000100300; Expressed in lower esophagus mucosa and 191 other tissues.
DR   ExpressionAtlas; B1AH88; baseline and differential.
DR   Genevisible; B1AH88; HS.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
PE   5: Uncertain;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..102
FT                   /note="Putative peripheral benzodiazepine receptor-related
FT                   protein"
FT                   /id="PRO_0000379595"
FT   VARIANT         53
FT                   /note="H -> R (in dbSNP:rs6971)"
FT                   /evidence="ECO:0000269|PubMed:8307574, ECO:0000269|Ref.2,
FT                   ECO:0000269|Ref.4"
FT                   /id="VAR_059840"
FT   CONFLICT        26
FT                   /note="G -> S (in Ref. 2; CAG33288)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   102 AA;  10537 MW;  E439ABAB50F56CA8 CRC64;
     MAPHLLWCPT NGLGLGGSPA GQWGGGSHYR GLVPGEPAGR PPALPLPGLA GLHDHTQLLR
     MAGQPWLAWG TAAARVSARP TRDCSCTSRC HHACDVVAVT LS