TSPO_BOVIN
ID TSPO_BOVIN Reviewed; 169 AA.
AC P30535; Q3ZC36;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Translocator protein;
DE AltName: Full=Isoquinoline-binding protein;
DE Short=IBP;
DE AltName: Full=PKBS;
DE AltName: Full=Peripheral-type benzodiazepine receptor;
DE Short=PBR;
GN Name=TSPO; Synonyms=BZRP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=1649835; DOI=10.1016/s0021-9258(18)92812-7;
RA Parola A.L., Stump D.G., Pepperl D.J., Krueger K.E., Regan J.W.,
RA Laird H.E. II;
RT "Cloning and expression of a pharmacologically unique bovine peripheral-
RT type benzodiazepine receptor isoquinoline binding protein.";
RL J. Biol. Chem. 266:14082-14087(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes the transport of cholesterol across mitochondrial
CC membranes and may play a role in lipid metabolism, but its precise
CC physiological role is controversial. It is apparently not required for
CC steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a
CC role in the transport of porphyrins and heme (By similarity). Was
CC initially identified as peripheral-type benzodiazepine receptor; can
CC also bind isoquinoline carboxamides (PubMed:1649835). {ECO:0000250,
CC ECO:0000269|PubMed:1649835}.
CC -!- SUBUNIT: Interacts with TSPOAP1. Interacts with MOST-1. May interact
CC with STAR. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:1649835};
CC Multi-pass membrane protein {ECO:0000269|PubMed:1649835}.
CC -!- SIMILARITY: Belongs to the TspO/BZRP family. {ECO:0000305}.
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DR EMBL; M64520; AAA30686.1; -; mRNA.
DR EMBL; BC102933; AAI02934.1; -; mRNA.
DR PIR; A39473; A39473.
DR RefSeq; NP_786970.1; NM_175776.2.
DR AlphaFoldDB; P30535; -.
DR SMR; P30535; -.
DR STRING; 9913.ENSBTAP00000024060; -.
DR PaxDb; P30535; -.
DR PRIDE; P30535; -.
DR GeneID; 281033; -.
DR KEGG; bta:281033; -.
DR CTD; 706; -.
DR eggNOG; KOG3797; Eukaryota.
DR HOGENOM; CLU_091805_2_1_1; -.
DR InParanoid; P30535; -.
DR OrthoDB; 1592225at2759; -.
DR TreeFam; TF342852; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd15904; TSPO_MBR; 1.
DR Gene3D; 1.20.1260.100; -; 1.
DR InterPro; IPR030164; TSPO.
DR InterPro; IPR038330; TspO/MBR-related_sf.
DR InterPro; IPR004307; TspO_MBR.
DR PANTHER; PTHR10057; PTHR10057; 1.
DR PANTHER; PTHR10057:SF5; PTHR10057:SF5; 1.
DR Pfam; PF03073; TspO_MBR; 1.
DR PIRSF; PIRSF005859; PBR; 1.
PE 2: Evidence at transcript level;
KW Lipid transport; Membrane; Mitochondrion; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..169
FT /note="Translocator protein"
FT /id="PRO_0000190996"
FT TOPO_DOM 1..5
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 27..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 68..79
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 80..100
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 101..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 106..126
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 127..134
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 135..155
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 156..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CONFLICT 148..149
FT /note="GM -> AT (in Ref. 2; AAI02934)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 169 AA; 18927 MW; 70E71E5B4C4BAC4C CRC64;
MAPPWVPAVG FTLLPSLGGF LGAQYTRGEG FRWYASLQKP PWHPPRWILA PIWGTLYSAM
GYGSYMIWKE LGGFSKEAVV PLGLYAGQLA LNWAWPPLFF GTRQMGWALV DLLLTGGMAA
ATAMAWHQVS PPAACLLYPY LAWLAFAGML NYRMWQDNQV RRSGRRLSE
