TSPO_HUMAN
ID TSPO_HUMAN Reviewed; 169 AA.
AC P30536; Q53Y59; Q6ICF9; Q96TF6;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 193.
DE RecName: Full=Translocator protein;
DE AltName: Full=Mitochondrial benzodiazepine receptor;
DE AltName: Full=PKBS;
DE AltName: Full=Peripheral-type benzodiazepine receptor;
DE Short=PBR;
GN Name=TSPO; Synonyms=BZRP, MBR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-147 AND HIS-162,
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=1847678; DOI=10.1111/j.1432-1033.1991.tb15707.x;
RA Riond J., Mattei M.-G., Kaghad M., Dumont X., Guillemot J.-C., le Fur G.,
RA Caput D., Ferrara P.;
RT "Molecular cloning and chromosomal localization of a human peripheral-type
RT benzodiazepine receptor.";
RL Eur. J. Biochem. 195:305-311(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7721091; DOI=10.1016/0378-1119(94)00817-c;
RA Yakovlev A.G., Ruffo M., Jurka J., Krueger K.E.;
RT "Comparison of repetitive elements in the third intron of human and rodent
RT mitochondrial benzodiazepine receptor-encoding genes.";
RL Gene 155:201-205(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=16189298; DOI=10.1124/mol.105.015289;
RA Costa B., Salvetti A., Rossi L., Spinetti F., Lena A., Chelli B.,
RA Rechichi M., Da Pozzo E., Gremigni V., Martini C.;
RT "Peripheral benzodiazepine receptor: characterization in human T-lymphoma
RT Jurkat cells.";
RL Mol. Pharmacol. 69:37-44(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ALA-147
RP AND HIS-162.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ALA-147
RP AND HIS-162.
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-147 AND GLN-169.
RG NIEHS SNPs program;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP INTERACTION WITH TSPOAP1.
RC TISSUE=Brain;
RX PubMed=9915832; DOI=10.1074/jbc.274.5.2938;
RA Galiegue S., Jbilo O., Combes T., Bribes E., Carayon P., Le Fur G.,
RA Casellas P.;
RT "Cloning and characterization of PRAX-1. A new protein that specifically
RT interacts with the peripheral benzodiazepine receptor.";
RL J. Biol. Chem. 274:2938-2952(1999).
RN [10]
RP NOMENCLATURE.
RX PubMed=16822554; DOI=10.1016/j.tips.2006.06.005;
RA Papadopoulos V., Baraldi M., Guilarte T.R., Knudsen T.B., Lacapere J.-J.,
RA Lindemann P., Norenberg M.D., Nutt D., Weizman A., Zhang M.-R., Gavish M.;
RT "Translocator protein (18kDa): new nomenclature for the peripheral-type
RT benzodiazepine receptor based on its structure and molecular function.";
RL Trends Pharmacol. Sci. 27:402-409(2006).
RN [11]
RP INTERACTION WITH MOST-1.
RX PubMed=17143515;
RA Tan J.M.M., Chow V.T.K.;
RT "Cellular expression, localization and interactions of the product of the
RT human MOST-1 gene associated with breast and prostate cancers.";
RL Int. J. Oncol. 30:81-89(2007).
RN [12]
RP TISSUE SPECIFICITY.
RX PubMed=20600583; DOI=10.1016/j.mce.2010.06.013;
RA Batarseh A., Papadopoulos V.;
RT "Regulation of translocator protein 18 kDa (TSPO) expression in health and
RT disease states.";
RL Mol. Cell. Endocrinol. 327:1-12(2010).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [14]
RP FUNCTION.
RX PubMed=24814875; DOI=10.1042/cs20140047;
RA Taylor J.M., Allen A.M., Graham A.;
RT "Targeting mitochondrial 18kDa translocator protein (TSPO) regulates
RT macrophage cholesterol efflux and lipid phenotype.";
RL Clin. Sci. 127:603-613(2014).
RN [15]
RP CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [16]
RP DEVELOPMENTAL STAGE.
RX PubMed=27641616; DOI=10.1038/srep33516;
RA Marginedas-Freixa I., Hattab C., Bouyer G., Halle F., Chene A.,
RA Lefevre S.D., Cambot M., Cueff A., Schmitt M., Gamain B., Lacapere J.J.,
RA Egee S., Bihel F., Le Van Kim C., Ostuni M.A.;
RT "TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to
RT the inhibition of P. falciparum growth in human blood.";
RL Sci. Rep. 6:33516-33516(2016).
RN [17]
RP VARIANTS ALA-147 AND HIS-162.
RX PubMed=11215759; DOI=10.1007/s007020070090;
RA Kurumaji A., Nomoto H., Yoshikawa T., Okubo Y., Toru M.;
RT "An association study between two missense variations of the benzodiazepine
RT receptor (peripheral) gene and schizophrenia in a Japanese sample.";
RL J. Neural Transm. 107:491-500(2000).
RN [18]
RP VARIANTS ALA-147 AND HIS-162.
RX PubMed=11304832; DOI=10.1002/ajmg.1194;
RA Kurumaji A., Nomoto H., Yamada K., Yoshikawa T., Toru M.;
RT "No association of two missense variations of the benzodiazepine receptor
RT (peripheral) gene and mood disorders in a Japanese sample.";
RL Am. J. Med. Genet. 105:172-175(2001).
RN [19]
RP CHARACTERIZATION OF VARIANT ALA-147.
RX PubMed=19846611; DOI=10.1210/en.2009-0752;
RA Costa B., Pini S., Gabelloni P., Da Pozzo E., Abelli M., Lari L., Preve M.,
RA Lucacchini A., Cassano G.B., Martini C.;
RT "The spontaneous Ala147Thr amino acid substitution within the translocator
RT protein influences pregnenolone production in lymphomonocytes of healthy
RT individuals.";
RL Endocrinology 150:5438-5445(2009).
CC -!- FUNCTION: Can bind protoporphyrin IX and may play a role in the
CC transport of porphyrins and heme (By similarity). Promotes the
CC transport of cholesterol across mitochondrial membranes and may play a
CC role in lipid metabolism (PubMed:24814875), but its precise
CC physiological role is controversial. It is apparently not required for
CC steroid hormone biosynthesis. Was initially identified as peripheral-
CC type benzodiazepine receptor; can also bind isoquinoline carboxamides
CC (PubMed:1847678). {ECO:0000250, ECO:0000269|PubMed:1847678,
CC ECO:0000269|PubMed:24814875}.
CC -!- SUBUNIT: Interacts with TSPOAP1 (By similarity). May interact with STAR
CC (By similarity). Interacts with MOST-1. {ECO:0000250,
CC ECO:0000269|PubMed:17143515, ECO:0000269|PubMed:9915832}.
CC -!- INTERACTION:
CC P30536; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-6623146, EBI-19125216;
CC P30536; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-6623146, EBI-2873246;
CC P30536; Q96BA8: CREB3L1; NbExp=7; IntAct=EBI-6623146, EBI-6942903;
CC P30536; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-6623146, EBI-18304435;
CC P30536; P32942: ICAM3; NbExp=3; IntAct=EBI-6623146, EBI-725421;
CC P30536; Q9H3M0: KCNF1; NbExp=3; IntAct=EBI-6623146, EBI-6918743;
CC P30536; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-6623146, EBI-17490413;
CC P30536; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-6623146, EBI-2820517;
CC P30536; Q6UWN5: LYPD5; NbExp=3; IntAct=EBI-6623146, EBI-17200970;
CC P30536; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-6623146, EBI-16439278;
CC P30536; Q68D85: NCR3LG1; NbExp=3; IntAct=EBI-6623146, EBI-14061804;
CC P30536; P15151: PVR; NbExp=3; IntAct=EBI-6623146, EBI-3919694;
CC P30536; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-6623146, EBI-8638294;
CC P30536; Q9P0T7: TMEM9; NbExp=3; IntAct=EBI-6623146, EBI-723976;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:1847678}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:1847678}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P30536-1; Sequence=Displayed;
CC Name=2; Synonyms=PBR-S;
CC IsoId=B1AH88-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Found in many tissue types. Expressed at the
CC highest levels under normal conditions in tissues that synthesize
CC steroids. {ECO:0000269|PubMed:20600583}.
CC -!- DEVELOPMENTAL STAGE: In erythrocytes, expression levels decrease
CC throughout differentiation (PubMed:27641616). Not expressed in mature
CC erythrocytes (PubMed:27641616). {ECO:0000269|PubMed:27641616}.
CC -!- SIMILARITY: Belongs to the TspO/BZRP family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/bzrp/";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M36035; AAA03652.1; -; mRNA.
DR EMBL; U12421; AAA83252.1; -; Genomic_DNA.
DR EMBL; AY998017; AAY45787.1; -; mRNA.
DR EMBL; BT006949; AAP35595.1; -; mRNA.
DR EMBL; CR456409; CAG30295.1; -; mRNA.
DR EMBL; AY383615; AAQ75703.1; -; Genomic_DNA.
DR EMBL; Z82214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001110; AAH01110.1; -; mRNA.
DR CCDS; CCDS33661.1; -. [P30536-1]
DR PIR; I38724; I38724.
DR PIR; JE0149; JE0149.
DR PIR; S14257; S14257.
DR RefSeq; NP_000705.2; NM_000714.5. [P30536-1]
DR RefSeq; NP_001243459.1; NM_001256530.1. [P30536-1]
DR RefSeq; NP_001243460.1; NM_001256531.1. [P30536-1]
DR AlphaFoldDB; P30536; -.
DR SMR; P30536; -.
DR BioGRID; 107168; 48.
DR IntAct; P30536; 19.
DR STRING; 9606.ENSP00000379563; -.
DR BindingDB; P30536; -.
DR ChEMBL; CHEMBL5742; -.
DR DrugBank; DB01178; Chlormezanone.
DR DrugBank; DB01198; Zopiclone.
DR DrugCentral; P30536; -.
DR GuidetoPHARMACOLOGY; 2879; -.
DR TCDB; 9.A.24.1.1; the mitochondrial cholesterol/porphyrin/5-aminolevulinic acid uptake translocator protein (tspo) family.
DR iPTMnet; P30536; -.
DR PhosphoSitePlus; P30536; -.
DR SwissPalm; P30536; -.
DR BioMuta; TSPO; -.
DR DMDM; 313104268; -.
DR EPD; P30536; -.
DR jPOST; P30536; -.
DR MassIVE; P30536; -.
DR MaxQB; P30536; -.
DR PaxDb; P30536; -.
DR PeptideAtlas; P30536; -.
DR PRIDE; P30536; -.
DR ProteomicsDB; 54717; -. [P30536-1]
DR TopDownProteomics; P30536-1; -. [P30536-1]
DR Antibodypedia; 27480; 290 antibodies from 40 providers.
DR DNASU; 706; -.
DR Ensembl; ENST00000329563.8; ENSP00000328973.4; ENSG00000100300.18. [P30536-1]
DR Ensembl; ENST00000337554.8; ENSP00000338004.3; ENSG00000100300.18. [P30536-1]
DR Ensembl; ENST00000396265.4; ENSP00000379563.4; ENSG00000100300.18. [P30536-1]
DR GeneID; 706; -.
DR KEGG; hsa:706; -.
DR MANE-Select; ENST00000337554.8; ENSP00000338004.3; NM_000714.6; NP_000705.2.
DR UCSC; uc003bdn.4; human. [P30536-1]
DR CTD; 706; -.
DR DisGeNET; 706; -.
DR GeneCards; TSPO; -.
DR HGNC; HGNC:1158; TSPO.
DR HPA; ENSG00000100300; Tissue enhanced (esophagus).
DR MIM; 109610; gene.
DR neXtProt; NX_P30536; -.
DR OpenTargets; ENSG00000100300; -.
DR PharmGKB; PA25473; -.
DR VEuPathDB; HostDB:ENSG00000100300; -.
DR eggNOG; KOG3797; Eukaryota.
DR GeneTree; ENSGT00390000012980; -.
DR HOGENOM; CLU_091805_2_1_1; -.
DR InParanoid; P30536; -.
DR OMA; GLNLIWM; -.
DR PhylomeDB; P30536; -.
DR TreeFam; TF342852; -.
DR PathwayCommons; P30536; -.
DR Reactome; R-HSA-196108; Pregnenolone biosynthesis.
DR SignaLink; P30536; -.
DR BioGRID-ORCS; 706; 8 hits in 1077 CRISPR screens.
DR ChiTaRS; TSPO; human.
DR GeneWiki; Translocator_protein; -.
DR GenomeRNAi; 706; -.
DR Pharos; P30536; Tchem.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; P30536; protein.
DR Bgee; ENSG00000100300; Expressed in lower esophagus mucosa and 191 other tissues.
DR ExpressionAtlas; P30536; baseline and differential.
DR Genevisible; P30536; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005497; F:androgen binding; IEA:Ensembl.
DR GO; GO:0008503; F:benzodiazepine receptor activity; TAS:ProtInc.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0120020; F:cholesterol transfer activity; TAS:Reactome.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0006820; P:anion transport; TAS:HGNC-UCL.
DR GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR GO; GO:0006700; P:C21-steroid hormone biosynthetic process; TAS:Reactome.
DR GO; GO:0071476; P:cellular hypotonic response; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0071294; P:cellular response to zinc ion; IEA:Ensembl.
DR GO; GO:0006821; P:chloride transport; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0060242; P:contact inhibition; IEA:Ensembl.
DR GO; GO:0008347; P:glial cell migration; IEA:Ensembl.
DR GO; GO:0006783; P:heme biosynthetic process; TAS:HGNC-UCL.
DR GO; GO:0072656; P:maintenance of protein location in mitochondrion; IEA:Ensembl.
DR GO; GO:1903579; P:negative regulation of ATP metabolic process; IEA:Ensembl.
DR GO; GO:1903147; P:negative regulation of autophagy of mitochondrion; IEA:Ensembl.
DR GO; GO:2000853; P:negative regulation of corticosterone secretion; IEA:Ensembl.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0014012; P:peripheral nervous system axon regeneration; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:0051901; P:positive regulation of mitochondrial depolarization; IEA:Ensembl.
DR GO; GO:0010940; P:positive regulation of necrotic cell death; IEA:Ensembl.
DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR GO; GO:0006626; P:protein targeting to mitochondrion; TAS:ProtInc.
DR GO; GO:0042127; P:regulation of cell population proliferation; TAS:HGNC-UCL.
DR GO; GO:0032374; P:regulation of cholesterol transport; TAS:HGNC-UCL.
DR GO; GO:0050810; P:regulation of steroid biosynthetic process; IEA:Ensembl.
DR GO; GO:1905144; P:response to acetylcholine; IEA:Ensembl.
DR GO; GO:0010042; P:response to manganese ion; IEA:Ensembl.
DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR GO; GO:0010266; P:response to vitamin B1; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0008202; P:steroid metabolic process; TAS:HGNC-UCL.
DR CDD; cd15904; TSPO_MBR; 1.
DR Gene3D; 1.20.1260.100; -; 1.
DR InterPro; IPR030164; TSPO.
DR InterPro; IPR038330; TspO/MBR-related_sf.
DR InterPro; IPR004307; TspO_MBR.
DR PANTHER; PTHR10057; PTHR10057; 1.
DR PANTHER; PTHR10057:SF5; PTHR10057:SF5; 1.
DR Pfam; PF03073; TspO_MBR; 1.
DR PIRSF; PIRSF005859; PBR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Lipid transport; Membrane; Mitochondrion; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CHAIN 2..169
FT /note="Translocator protein"
FT /id="PRO_0000190997"
FT TOPO_DOM 2..5
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 27..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 68..79
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 80..100
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 101..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 106..126
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 127..134
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 135..155
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 156..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT VARIANT 147
FT /note="T -> A (associated with higher levels of
FT pregnenolone production by lymphomonocytes and with
FT increased plasma levels of cholesterol-rich low density
FT lipoprotein; dbSNP:rs6971)"
FT /evidence="ECO:0000269|PubMed:11215759,
FT ECO:0000269|PubMed:11304832, ECO:0000269|PubMed:15461802,
FT ECO:0000269|PubMed:1847678, ECO:0000269|PubMed:19846611,
FT ECO:0000269|Ref.4, ECO:0000269|Ref.6"
FT /id="VAR_013617"
FT VARIANT 162
FT /note="R -> H (in dbSNP:rs6972)"
FT /evidence="ECO:0000269|PubMed:11215759,
FT ECO:0000269|PubMed:11304832, ECO:0000269|PubMed:15461802,
FT ECO:0000269|PubMed:1847678, ECO:0000269|Ref.4"
FT /id="VAR_013618"
FT VARIANT 169
FT /note="E -> Q (in dbSNP:rs9333342)"
FT /evidence="ECO:0000269|Ref.6"
FT /id="VAR_018868"
SQ SEQUENCE 169 AA; 18828 MW; 6DD741BF99AB89D9 CRC64;
MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM
GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA
ATTVAWYQVS PLAARLLYPY LAWLAFTTTL NYCVWRDNHG WRGGRRLPE
