ID   TSPO_PIG                Reviewed;         169 AA.
AC   Q6UN27;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Translocator protein;
DE   AltName: Full=Peripheral-type benzodiazepine receptor;
DE            Short=PBR;
GN   Name=TSPO; Synonyms=BZRP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Adrenal gland;
RX   PubMed=17019653; DOI=10.1007/s00335-006-0022-x;
RA   Zhang K., Demeure O., Belliard A., Goujon J.M., Favreau F., Desurmont T.,
RA   Mauco G., Barriere M., Carretier M., Milan D., Papadopoulos V., Hauet T.;
RT   "Cloning, sequencing, and chromosomal localization of pig peripheral
RT   benzodiazepine receptor: three different forms produced by alternative
RT   splicing.";
RL   Mamm. Genome 17:1050-1062(2006).
CC   -!- FUNCTION: Promotes the transport of cholesterol across mitochondrial
CC       membranes and may play a role in lipid metabolism, but its precise
CC       physiological role is controversial. It is apparently not required for
CC       steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a
CC       role in the transport of porphyrins and heme. Was initially identified
CC       as peripheral-type benzodiazepine receptor; can also bind isoquinoline
CC       carboxamides (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TSPOAP1. Interacts with MOST-1. May interact
CC       with STAR. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000269|PubMed:17019653}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:17019653}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:17019653}.
CC   -!- SIMILARITY: Belongs to the TspO/BZRP family. {ECO:0000305}.
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DR   EMBL; AY366497; AAQ72807.1; -; mRNA.
DR   RefSeq; NP_998918.1; NM_213753.1.
DR   AlphaFoldDB; Q6UN27; -.
DR   SMR; Q6UN27; -.
DR   STRING; 9823.ENSSSCP00000000035; -.
DR   PaxDb; Q6UN27; -.
DR   PeptideAtlas; Q6UN27; -.
DR   Ensembl; ENSSSCT00025016911; ENSSSCP00025006754; ENSSSCG00025012766.
DR   Ensembl; ENSSSCT00035032659; ENSSSCP00035012859; ENSSSCG00035024827.
DR   Ensembl; ENSSSCT00045014035; ENSSSCP00045009709; ENSSSCG00045008320.
DR   GeneID; 396592; -.
DR   KEGG; ssc:396592; -.
DR   CTD; 706; -.
DR   eggNOG; KOG3797; Eukaryota.
DR   InParanoid; Q6UN27; -.
DR   OrthoDB; 1592225at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd15904; TSPO_MBR; 1.
DR   Gene3D; 1.20.1260.100; -; 1.
DR   InterPro; IPR030164; TSPO.
DR   InterPro; IPR038330; TspO/MBR-related_sf.
DR   InterPro; IPR004307; TspO_MBR.
DR   PANTHER; PTHR10057; PTHR10057; 1.
DR   PANTHER; PTHR10057:SF5; PTHR10057:SF5; 1.
DR   Pfam; PF03073; TspO_MBR; 1.
DR   PIRSF; PIRSF005859; PBR; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Membrane; Mitochondrion; Receptor; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..169
FT                   /note="Translocator protein"
FT                   /id="PRO_0000331457"
FT   TOPO_DOM        1..5
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        27..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        68..79
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        80..100
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        101..105
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        106..126
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        127..134
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        156..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   169 AA;  18609 MW;  DDB680ABF692422F CRC64;
     MAPPWLPAVG FTLVPSLGGF LSSRNVLGKG LHWYAGLQKP SWHPPHWTLA PIWGTLYSAM
     GYGSYMIWKE LGGFSEEAVV PLGLYAGQLA LNWAWPPLFF GARQMGWALV DLVLTGGVAA
     ATAVAWYQVS PLAARLLYPY LAWLAFAATL NYCVWRDNQG RRGGRRPSE