ID   TSPO_SHEEP              Reviewed;         169 AA.
AC   Q9GMC9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Translocator protein;
DE   AltName: Full=Peripheral-type benzodiazepine receptor;
DE            Short=PBR;
GN   Name=TSPO; Synonyms=BZRP;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
RP   WITH STAR.
RX   PubMed=11145616; DOI=10.1210/endo.142.1.8052;
RA   West L.A., Horvat R.D., Roess D.A., Barisas B.G., Juengel J.L.,
RA   Niswender G.D.;
RT   "Steroidogenic acute regulatory protein and peripheral-type benzodiazepine
RT   receptor associate at the mitochondrial membrane.";
RL   Endocrinology 142:502-505(2001).
CC   -!- FUNCTION: Promotes the transport of cholesterol across mitochondrial
CC       membranes and may play a role in lipid metabolism, but its precise
CC       physiological role is controversial. It is apparently not required for
CC       steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a
CC       role in the transport of porphyrins and heme (By similarity). Was
CC       initially identified as peripheral-type benzodiazepine receptor; can
CC       also bind isoquinoline carboxamides (PubMed:11145616). {ECO:0000250,
CC       ECO:0000269|PubMed:11145616}.
CC   -!- SUBUNIT: Interacts with TSPOAP1 (By similarity). Interacts with MOST-1
CC       (By similarity). May interact with STAR. {ECO:0000250,
CC       ECO:0000269|PubMed:11145616}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000269|PubMed:11145616}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:11145616}.
CC   -!- SIMILARITY: Belongs to the TspO/BZRP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF290203; AAG02465.1; -; mRNA.
DR   RefSeq; NP_001009747.1; NM_001009747.1.
DR   AlphaFoldDB; Q9GMC9; -.
DR   SMR; Q9GMC9; -.
DR   STRING; 9940.ENSOARP00000020560; -.
DR   GeneID; 443123; -.
DR   KEGG; oas:443123; -.
DR   CTD; 706; -.
DR   eggNOG; KOG3797; Eukaryota.
DR   OrthoDB; 1592225at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd15904; TSPO_MBR; 1.
DR   Gene3D; 1.20.1260.100; -; 1.
DR   InterPro; IPR030164; TSPO.
DR   InterPro; IPR038330; TspO/MBR-related_sf.
DR   InterPro; IPR004307; TspO_MBR.
DR   PANTHER; PTHR10057; PTHR10057; 1.
DR   PANTHER; PTHR10057:SF5; PTHR10057:SF5; 1.
DR   Pfam; PF03073; TspO_MBR; 1.
DR   PIRSF; PIRSF005859; PBR; 1.
PE   1: Evidence at protein level;
KW   Lipid transport; Membrane; Mitochondrion; Receptor; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..169
FT                   /note="Translocator protein"
FT                   /id="PRO_0000331458"
FT   TOPO_DOM        1..5
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        27..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        68..79
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        80..100
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        101..105
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        106..126
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        127..134
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        156..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   169 AA;  18916 MW;  F86FBD9B0149484F CRC64;
     MAPPWVPAVG FTLVPSPGGF LGTQYIRGEG FRWYASLQKP PWHPPRWILA PIWGTLYSAM
     GYGSYLIWKE LGGFSKEAVV PLGLYAGQLA LNWAWPPLFF GARQMGWAFV DLLLTGGMAA
     ATAMAWRQVS PPAACLLYPY LAWLAFAAML NYRMWQDNQG RRSGRRLSE