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TSPY1_BOVIN
ID   TSPY1_BOVIN             Reviewed;         317 AA.
AC   O19110; O19106; O19107; O19109; O19185;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Testis-specific Y-encoded protein 1;
DE   AltName: Full=bTSPY;
GN   Name=TSPY1; Synonyms=TSPY;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS LEU-306 AND
RP   MET-314, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Testis;
RX   PubMed=9195993; DOI=10.1007/s003359900482;
RA   Vogel T., Dechend F., Manz E., Jung C., Jakubiczka S., Fehr S.,
RA   Schmidtke J., Schnieders F.;
RT   "Organization and expression of bovine TSPY.";
RL   Mamm. Genome 8:491-496(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 145-206, AND TISSUE SPECIFICITY.
RC   STRAIN=Holstein;
RX   PubMed=8244389; DOI=10.1006/geno.1993.1394;
RA   Jakubiczka S., Schnieders F., Schmidtke J.;
RT   "A bovine homologue of the human TSPY gene.";
RL   Genomics 17:732-735(1993).
CC   -!- FUNCTION: May be involved in sperm differentiation and proliferation.
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus
CC       {ECO:0000250|UniProtKB:Q01534}. Note=Predominantly cytoplasmic. Also
CC       found in nucleus. {ECO:0000250|UniProtKB:Q01534}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O19110-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O19110-2; Sequence=VSP_008013;
CC   -!- TISSUE SPECIFICITY: Testis. Probably in spermatogonia.
CC       {ECO:0000269|PubMed:8244389, ECO:0000269|PubMed:9195993}.
CC   -!- DEVELOPMENTAL STAGE: Detected in 6 and 7-week-old testis.
CC       {ECO:0000269|PubMed:9195993}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Maps to a tandemly repeated region on chromosome Y. Between 50
CC       and 200 copies per Y chromosome are reported. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB72142.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U75889; AAB72137.1; -; mRNA.
DR   EMBL; U75890; AAB72138.1; -; mRNA.
DR   EMBL; U75891; AAB72139.1; -; mRNA.
DR   EMBL; U75892; AAB72140.1; -; mRNA.
DR   EMBL; U75894; AAB72142.1; ALT_INIT; mRNA.
DR   EMBL; U75896; AAB72143.1; -; mRNA.
DR   EMBL; X74028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; O19110; -.
DR   SMR; O19110; -.
DR   STRING; 9913.ENSBTAP00000052745; -.
DR   PaxDb; O19110; -.
DR   PRIDE; O19110; -.
DR   eggNOG; KOG1508; Eukaryota.
DR   InParanoid; O19110; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW   Gonadal differentiation; Nucleus; Phosphoprotein; Reference proteome;
KW   Spermatogenesis.
FT   CHAIN           1..317
FT                   /note="Testis-specific Y-encoded protein 1"
FT                   /id="PRO_0000185667"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         312..317
FT                   /note="SSVRDN -> RTQ (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:9195993"
FT                   /id="VSP_008013"
FT   VARIANT         306
FT                   /note="Y -> L"
FT                   /evidence="ECO:0000269|PubMed:9195993"
FT   VARIANT         314
FT                   /note="V -> M"
FT                   /evidence="ECO:0000269|PubMed:9195993"
FT   CONFLICT        168
FT                   /note="T -> A (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   317 AA;  36619 MW;  2144FAF373612157 CRC64;
     MSRPFASAPA RGHRQGQEER ERRSEEGGSV PGPRTFQVVS PVVTPGQEAT LFRVEAVEEG
     EARHEGDVAG IGREFQLLAE DIVEEVEVVA DEEQEQRPSQ ELEEKTVEEQ GQERPGGPCE
     RQELDALQAL AALQVELSSE REQNRRAYVQ FMRKNHQRRK RHLARRSTII QGIPGFWAKA
     IMSHPQVSVL ISDQDQDFLG YMMDLKVQVR SHPPSRCKLI FSFRDNPYFL NSVIIKEYYL
     DITGYRARRS TPVHWFWDFE RGAPSRRRDT RSLNFLNWLS GHNGPESNRI AEIISEDVWD
     DPLKYYLREE GSSVRDN
 
 
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