TSPY1_BOVIN
ID TSPY1_BOVIN Reviewed; 317 AA.
AC O19110; O19106; O19107; O19109; O19185;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Testis-specific Y-encoded protein 1;
DE AltName: Full=bTSPY;
GN Name=TSPY1; Synonyms=TSPY;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS LEU-306 AND
RP MET-314, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Testis;
RX PubMed=9195993; DOI=10.1007/s003359900482;
RA Vogel T., Dechend F., Manz E., Jung C., Jakubiczka S., Fehr S.,
RA Schmidtke J., Schnieders F.;
RT "Organization and expression of bovine TSPY.";
RL Mamm. Genome 8:491-496(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 145-206, AND TISSUE SPECIFICITY.
RC STRAIN=Holstein;
RX PubMed=8244389; DOI=10.1006/geno.1993.1394;
RA Jakubiczka S., Schnieders F., Schmidtke J.;
RT "A bovine homologue of the human TSPY gene.";
RL Genomics 17:732-735(1993).
CC -!- FUNCTION: May be involved in sperm differentiation and proliferation.
CC {ECO:0000250|UniProtKB:Q01534}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus
CC {ECO:0000250|UniProtKB:Q01534}. Note=Predominantly cytoplasmic. Also
CC found in nucleus. {ECO:0000250|UniProtKB:Q01534}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O19110-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O19110-2; Sequence=VSP_008013;
CC -!- TISSUE SPECIFICITY: Testis. Probably in spermatogonia.
CC {ECO:0000269|PubMed:8244389, ECO:0000269|PubMed:9195993}.
CC -!- DEVELOPMENTAL STAGE: Detected in 6 and 7-week-old testis.
CC {ECO:0000269|PubMed:9195993}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
CC -!- CAUTION: Maps to a tandemly repeated region on chromosome Y. Between 50
CC and 200 copies per Y chromosome are reported. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB72142.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U75889; AAB72137.1; -; mRNA.
DR EMBL; U75890; AAB72138.1; -; mRNA.
DR EMBL; U75891; AAB72139.1; -; mRNA.
DR EMBL; U75892; AAB72140.1; -; mRNA.
DR EMBL; U75894; AAB72142.1; ALT_INIT; mRNA.
DR EMBL; U75896; AAB72143.1; -; mRNA.
DR EMBL; X74028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; O19110; -.
DR SMR; O19110; -.
DR STRING; 9913.ENSBTAP00000052745; -.
DR PaxDb; O19110; -.
DR PRIDE; O19110; -.
DR eggNOG; KOG1508; Eukaryota.
DR InParanoid; O19110; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Gonadal differentiation; Nucleus; Phosphoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..317
FT /note="Testis-specific Y-encoded protein 1"
FT /id="PRO_0000185667"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 312..317
FT /note="SSVRDN -> RTQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9195993"
FT /id="VSP_008013"
FT VARIANT 306
FT /note="Y -> L"
FT /evidence="ECO:0000269|PubMed:9195993"
FT VARIANT 314
FT /note="V -> M"
FT /evidence="ECO:0000269|PubMed:9195993"
FT CONFLICT 168
FT /note="T -> A (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 36619 MW; 2144FAF373612157 CRC64;
MSRPFASAPA RGHRQGQEER ERRSEEGGSV PGPRTFQVVS PVVTPGQEAT LFRVEAVEEG
EARHEGDVAG IGREFQLLAE DIVEEVEVVA DEEQEQRPSQ ELEEKTVEEQ GQERPGGPCE
RQELDALQAL AALQVELSSE REQNRRAYVQ FMRKNHQRRK RHLARRSTII QGIPGFWAKA
IMSHPQVSVL ISDQDQDFLG YMMDLKVQVR SHPPSRCKLI FSFRDNPYFL NSVIIKEYYL
DITGYRARRS TPVHWFWDFE RGAPSRRRDT RSLNFLNWLS GHNGPESNRI AEIISEDVWD
DPLKYYLREE GSSVRDN