ID   TSPY2_HUMAN             Reviewed;         308 AA.
AC   A6NKD2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Testis-specific Y-encoded protein 2;
DE   AltName: Full=Testis-specific Y-encoded protein Q1;
GN   Name=TSPY2; Synonyms=TSPYQ1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
CC   -!- FUNCTION: May be involved in sperm differentiation and proliferation.
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- INTERACTION:
CC       A6NKD2; Q9C005: DPY30; NbExp=3; IntAct=EBI-12817075, EBI-744973;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- POLYMORPHISM: Maps to a tandemly repeated region on chromosome Yp11;
CC       additionally at least one copy is reported originating from Yq. The
CC       gene is thought to be present with an inter-individual variation in
CC       copy number and between 20 and 60 copies per Y chromosome are expected.
CC       PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11
CC       originating from one individual.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
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DR   EMBL; AC006335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS35465.1; -.
DR   RefSeq; NP_072095.2; NM_022573.2.
DR   AlphaFoldDB; A6NKD2; -.
DR   SMR; A6NKD2; -.
DR   BioGRID; 122212; 18.
DR   IntAct; A6NKD2; 2.
DR   GlyGen; A6NKD2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A6NKD2; -.
DR   PhosphoSitePlus; A6NKD2; -.
DR   BioMuta; TSPY2; -.
DR   jPOST; A6NKD2; -.
DR   MassIVE; A6NKD2; -.
DR   MaxQB; A6NKD2; -.
DR   PaxDb; A6NKD2; -.
DR   PRIDE; A6NKD2; -.
DR   ProteomicsDB; 1403; -.
DR   Antibodypedia; 21852; 14 antibodies from 10 providers.
DR   DNASU; 64591; -.
DR   Ensembl; ENST00000320701.9; ENSP00000314077.4; ENSG00000168757.13.
DR   GeneID; 64591; -.
DR   KEGG; hsa:64591; -.
DR   MANE-Select; ENST00000320701.9; ENSP00000314077.4; NM_022573.4; NP_072095.2.
DR   UCSC; uc004fqr.2; human.
DR   CTD; 64591; -.
DR   GeneCards; TSPY2; -.
DR   HGNC; HGNC:23924; TSPY2.
DR   HPA; ENSG00000168757; Tissue enriched (testis).
DR   neXtProt; NX_A6NKD2; -.
DR   PharmGKB; PA134958857; -.
DR   VEuPathDB; HostDB:ENSG00000168757; -.
DR   GeneTree; ENSGT00940000162417; -.
DR   HOGENOM; CLU_051687_1_0_1; -.
DR   InParanoid; A6NKD2; -.
DR   OMA; WIAEIIV; -.
DR   OrthoDB; 1191764at2759; -.
DR   PhylomeDB; A6NKD2; -.
DR   TreeFam; TF313386; -.
DR   PathwayCommons; A6NKD2; -.
DR   SignaLink; A6NKD2; -.
DR   BioGRID-ORCS; 64591; 9 hits in 240 CRISPR screens.
DR   GenomeRNAi; 64591; -.
DR   Pharos; A6NKD2; Tdark.
DR   PRO; PR:A6NKD2; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   RNAct; A6NKD2; protein.
DR   Bgee; ENSG00000168757; Expressed in right testis and 35 other tissues.
DR   ExpressionAtlas; A6NKD2; baseline and differential.
DR   Genevisible; A6NKD2; HS.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation; Gonadal differentiation;
KW   Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..308
FT                   /note="Testis-specific Y-encoded protein 2"
FT                   /id="PRO_0000333197"
SQ   SEQUENCE   308 AA;  35100 MW;  244AF6DEC39277FE CRC64;
     MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
     EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESALE ELLAVQVELE
     PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM
     LSYMVSLEVE EEKHRVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD
     YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET
     SGDSQLLS