C42S1_BOVIN
ID C42S1_BOVIN Reviewed; 79 AA.
AC Q5BIS3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=CDC42 small effector protein 1;
GN Name=CDC42SE1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably involved in the organization of the actin
CC cytoskeleton by acting downstream of CDC42, inducing actin filament
CC assembly. Alters CDC42-induced cell shape changes. In activated T-
CC cells, may play a role in CDC42-mediated F-actin accumulation at the
CC immunological synapse. May play a role in early contractile events in
CC phagocytosis in macrophages (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CDC42 (in GTP-bound form). Interacts weakly
CC with RAC1 and not at all with RHOA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC -!- DOMAIN: The CRIB domain mediates interaction with CDC42. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDC42SE/SPEC family. {ECO:0000305}.
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DR EMBL; BT021151; AAX31333.1; -; mRNA.
DR EMBL; BC102825; AAI02826.1; -; mRNA.
DR RefSeq; NP_001030284.1; NM_001035112.1.
DR RefSeq; XP_015318260.1; XM_015462774.1.
DR AlphaFoldDB; Q5BIS3; -.
DR STRING; 9913.ENSBTAP00000020417; -.
DR PaxDb; Q5BIS3; -.
DR PRIDE; Q5BIS3; -.
DR GeneID; 614042; -.
DR KEGG; bta:614042; -.
DR CTD; 56882; -.
DR eggNOG; ENOG502S499; Eukaryota.
DR HOGENOM; CLU_173417_1_0_1; -.
DR InParanoid; Q5BIS3; -.
DR OrthoDB; 1646014at2759; -.
DR TreeFam; TF323815; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR Gene3D; 3.90.810.10; -; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR039056; SPEC.
DR PANTHER; PTHR13502; PTHR13502; 1.
DR PROSITE; PS50108; CRIB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell shape; Cytoplasm; Cytoskeleton; Lipoprotein; Membrane;
KW Palmitate; Phagocytosis; Reference proteome.
FT CHAIN 1..79
FT /note="CDC42 small effector protein 1"
FT /id="PRO_0000334628"
FT DOMAIN 30..43
FT /note="CRIB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT REGION 48..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 10
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 11
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8925 MW; D1C1DCEBD339EF5B CRC64;
MSEFWHKLGC CVVEKPQPKK KRRRIDRTMI GEPMNFVHLT HIGSGEMGAG DGLAMTGAVQ
EQMRSKGNRD RPWSNSRGL
