ID   TSPY4_HUMAN             Reviewed;         314 AA.
AC   P0CV99;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Testis-specific Y-encoded protein 4;
GN   Name=TSPY4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
CC   -!- FUNCTION: May be involved in sperm differentiation and proliferation.
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- POLYMORPHISM: Maps to a tandemly repeated region on chromosome Yp11;
CC       additionally at least one copy is reported originating from Yq. The
CC       gene is thought to be present with an inter-individual variation in
CC       copy number and between 20 and 60 copies per Y chromosome are expected.
CC       35 tandemly repeated gene copies on Yp11 originating from one
CC       individual have been reported (PubMed:12815422).
CC       {ECO:0000269|PubMed:12815422}.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
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DR   EMBL; AC006158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS48202.1; -.
DR   RefSeq; NP_001157943.1; NM_001164471.1.
DR   AlphaFoldDB; P0CV99; -.
DR   SMR; P0CV99; -.
DR   IntAct; P0CV99; 1.
DR   BioMuta; TSPY4; -.
DR   DMDM; 332321775; -.
DR   jPOST; P0CV99; -.
DR   MassIVE; P0CV99; -.
DR   MaxQB; P0CV99; -.
DR   PaxDb; P0CV99; -.
DR   PeptideAtlas; P0CV99; -.
DR   PRIDE; P0CV99; -.
DR   Antibodypedia; 71183; 5 antibodies from 5 providers.
DR   DNASU; 728395; -.
DR   Ensembl; ENST00000426950.6; ENSP00000399668.2; ENSG00000233803.9.
DR   GeneID; 728395; -.
DR   KEGG; hsa:728395; -.
DR   MANE-Select; ENST00000426950.6; ENSP00000399668.2; NM_001164471.2; NP_001157943.1.
DR   CTD; 728395; -.
DR   GeneCards; TSPY4; -.
DR   HGNC; HGNC:37287; TSPY4.
DR   HPA; ENSG00000233803; Tissue enriched (testis).
DR   neXtProt; NX_P0CV99; -.
DR   VEuPathDB; HostDB:ENSG00000233803; -.
DR   GeneTree; ENSGT00940000162417; -.
DR   HOGENOM; CLU_051687_1_0_1; -.
DR   InParanoid; P0CV99; -.
DR   OMA; QNIPDFW; -.
DR   OrthoDB; 1191764at2759; -.
DR   PhylomeDB; P0CV99; -.
DR   TreeFam; TF313386; -.
DR   BioGRID-ORCS; 728395; 8 hits in 148 CRISPR screens.
DR   GenomeRNAi; 728395; -.
DR   Pharos; P0CV99; Tdark.
DR   PRO; PR:P0CV99; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   RNAct; P0CV99; protein.
DR   Bgee; ENSG00000233803; Expressed in right testis and 27 other tissues.
DR   ExpressionAtlas; P0CV99; baseline.
DR   Genevisible; P0CV99; HS.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Differentiation; Gonadal differentiation;
KW   Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..314
FT                   /note="Testis-specific Y-encoded protein 4"
FT                   /id="PRO_0000408002"
SQ   SEQUENCE   314 AA;  35727 MW;  3B226B3C96F703F4 CRC64;
     MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
     EEAVLLLDDI MAEVEVVAEV EVVAEEEGLV ERREEAQRAQ QAVPGPGPMT PESALEELLA
     VQVELEPVNA QARKAFSRQR EKMERRRKPH LDRRGAVIQS VPGFWANVIA NHPQMSALIT
     DEDEDMLSYM VSLEVEEEKH PVHLCKIMLF FRSNPYFQNK VITKEYLVNI TEYRASHSTP
     IEWYPDYEVE AYRRRHHNSS LNFFNWFSDH NFAGSNKIAE ILCKDLWRNP LQYYKRMKPP
     EEGTETSGDS QLLS