ID   TSPY8_HUMAN             Reviewed;         308 AA.
AC   P0CW00; H7BXJ3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Testis-specific Y-encoded protein 8;
GN   Name=TSPY8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
CC   -!- FUNCTION: May be involved in sperm differentiation and proliferation.
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus
CC       {ECO:0000250|UniProtKB:Q01534}.
CC   -!- POLYMORPHISM: Maps to a tandemly repeated region on chromosome Yp11;
CC       additionally at least one copy is reported originating from Yq. The
CC       gene is thought to be present with an inter-individual variation in
CC       copy number and between 20 and 60 copies per Y chromosome are expected.
CC       35 tandemly repeated gene copies on Yp11 originating from one
CC       individual have been reported (PubMed:12815422).
CC       {ECO:0000269|PubMed:12815422}.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
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DR   EMBL; AC006158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59533.1; -.
DR   RefSeq; NP_001230650.1; NM_001243721.1.
DR   AlphaFoldDB; P0CW00; -.
DR   SMR; P0CW00; -.
DR   BioGRID; 608830; 2.
DR   IntAct; P0CW00; 1.
DR   BioMuta; TSPY8; -.
DR   DMDM; 510120716; -.
DR   jPOST; P0CW00; -.
DR   MassIVE; P0CW00; -.
DR   MaxQB; P0CW00; -.
DR   PeptideAtlas; P0CW00; -.
DR   PRIDE; P0CW00; -.
DR   ProteomicsDB; 43301; -.
DR   DNASU; 728403; -.
DR   Ensembl; ENST00000287721.13; ENSP00000287721.9; ENSG00000229549.9.
DR   GeneID; 728403; -.
DR   KEGG; hsa:728403; -.
DR   MANE-Select; ENST00000287721.13; ENSP00000287721.9; NM_001243721.2; NP_001230650.1.
DR   UCSC; uc004frr.3; human.
DR   CTD; 728403; -.
DR   GeneCards; TSPY8; -.
DR   HGNC; HGNC:37471; TSPY8.
DR   HPA; ENSG00000229549; Tissue enriched (testis).
DR   neXtProt; NX_P0CW00; -.
DR   VEuPathDB; HostDB:ENSG00000229549; -.
DR   GeneTree; ENSGT00940000162417; -.
DR   InParanoid; P0CW00; -.
DR   OMA; EMIVKEY; -.
DR   OrthoDB; 1191764at2759; -.
DR   PhylomeDB; P0CW00; -.
DR   BioGRID-ORCS; 728403; 17 hits in 232 CRISPR screens.
DR   GenomeRNAi; 728403; -.
DR   Pharos; P0CW00; Tdark.
DR   PRO; PR:P0CW00; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   RNAct; P0CW00; protein.
DR   Bgee; ENSG00000229549; Expressed in right testis and 31 other tissues.
DR   ExpressionAtlas; P0CW00; baseline.
DR   Genevisible; P0CW00; HS.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Differentiation; Gonadal differentiation;
KW   Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..308
FT                   /note="Testis-specific Y-encoded protein 8"
FT                   /id="PRO_0000408003"
SQ   SEQUENCE   308 AA;  35147 MW;  C253A62F95CC4DC2 CRC64;
     MRPEGSLTYW VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
     EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESALE ELLAVQVELE
     PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM
     LSYMVSLEVE EEKHPVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYLD
     YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET
     SGDSQLLS