ID   TSR1_CAEBR              Reviewed;         788 AA.
AC   Q61WR2; A8WX60;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Pre-rRNA-processing protein TSR1 homolog;
GN   Name=tag-151; ORFNames=CBG04291;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC       the nucleolus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Bms1-like GTPase family. TSR1 subfamily. {ECO:0000305}.
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DR   EMBL; HE600920; CAP25030.3; -; Genomic_DNA.
DR   RefSeq; XP_002630359.1; XM_002630313.1.
DR   AlphaFoldDB; Q61WR2; -.
DR   SMR; Q61WR2; -.
DR   STRING; 6238.CBG04291; -.
DR   EnsemblMetazoa; CBG04291.1; CBG04291.1; WBGene00026999.
DR   GeneID; 8571874; -.
DR   KEGG; cbr:CBG_04291; -.
DR   CTD; 8571874; -.
DR   WormBase; CBG04291; CBP01116; WBGene00026999; Cbr-tag-151.
DR   eggNOG; KOG1980; Eukaryota.
DR   HOGENOM; CLU_009858_1_0_1; -.
DR   InParanoid; Q61WR2; -.
DR   OMA; KTPHQQV; -.
DR   OrthoDB; 186926at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   InterPro; IPR012948; AARP2CN.
DR   InterPro; IPR039761; Bms1/Tsr1.
DR   InterPro; IPR007034; BMS1_TSR1_C.
DR   InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR   PANTHER; PTHR12858; PTHR12858; 1.
DR   Pfam; PF08142; AARP2CN; 1.
DR   Pfam; PF04950; RIBIOP_C; 1.
DR   SMART; SM00785; AARP2CN; 1.
DR   SMART; SM01362; DUF663; 1.
DR   PROSITE; PS51714; G_BMS1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..788
FT                   /note="Pre-rRNA-processing protein TSR1 homolog"
FT                   /id="PRO_0000311278"
FT   DOMAIN          83..243
FT                   /note="Bms1-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01051"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..414
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  89693 MW;  6E1E1A217431FF22 CRC64;
     MSTTGHRAGV FKKPAKPHKS WKGKRTKGEI TTENRGREGV KQLTRSAHST HRAVSKDARR
     NQLKMARDRK MADAMERRRT SNAPCLVTIL SLGVGARPSE FLKKLATCDE TIVQTHSPST
     IDFAIPRFKS RISFLTPDKE NVDSVLDAIR ASDVLCFLWP LSAELSEWDE QLLTICKAAG
     LPTIVSVVPG LGGIQNHKKK EDVRKGIEFT ISKWSMSNAG VMPADSVTDN LQLLRTLNET
     KKKPLTLQAR HSYMLVENLE ATESPEDSSK ITLKAQGYLR GPEWNANNLI HLPGFGDFQI
     SKIETAADPH PLKTSPPKGA EVIAKADEKR QSLETEITLD AMDGEQTWPT QEELEEADKE
     MRRVPKGTSS YQAAWILDDS EDDEDEEDED EDMDDEEEDK DLEEDDEEED TPMDLKSEAG
     ETTASEMMFH DEIDEDINLA EVEKYRKERE NAQWPDEVDT PIDQPARIRF QKYRGLKSFR
     TSTWDAKENL PVDYARIFQF ANYKNTKKNV MSKIGGNDVD AGDAVIDKKF NGVFASVYIE
     NVPVSVMEAY KETKNLVLFQ LLPHEQKMSI LNMVLKKHPS CTVPIGSEDQ KFIFYVGFRQ
     FEAHAVLSSN TPGDKFKLER FMPTEKTFVA TVYAPITFNP ATVLCFRQDD KGRQELVATG
     SVLDTNPDRI VLKRTVLSGH PYKINRRAVV VRYMFFNRED IDWFKPVELY TPSGRRGHIK
     EAVGTHGHMK CRFDQQLNAQ DSVMLNLYKR VFPVWDYSLF NRNLNPSRFV ERSRVESISL
     VQEDAMEE