TSR1_DICDI
ID TSR1_DICDI Reviewed; 826 AA.
AC Q54YA7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Pre-rRNA-processing protein TSR1 homolog;
GN Name=tsr1; ORFNames=DDB_G0278331;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC the nucleolus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Bms1-like GTPase family. TSR1 subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000023; EAL68338.1; -; Genomic_DNA.
DR RefSeq; XP_642295.1; XM_637203.1.
DR AlphaFoldDB; Q54YA7; -.
DR SMR; Q54YA7; -.
DR STRING; 44689.DDB0205380; -.
DR PaxDb; Q54YA7; -.
DR PRIDE; Q54YA7; -.
DR EnsemblProtists; EAL68338; EAL68338; DDB_G0278331.
DR GeneID; 8621502; -.
DR KEGG; ddi:DDB_G0278331; -.
DR dictyBase; DDB_G0278331; -.
DR eggNOG; KOG1980; Eukaryota.
DR HOGENOM; CLU_009858_1_0_1; -.
DR InParanoid; Q54YA7; -.
DR OMA; KTPHQQV; -.
DR PhylomeDB; Q54YA7; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q54YA7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR PANTHER; PTHR12858; PTHR12858; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..826
FT /note="Pre-rRNA-processing protein TSR1 homolog"
FT /id="PRO_0000339129"
FT DOMAIN 86..261
FT /note="Bms1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01051"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..465
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..513
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 95855 MW; BA06292A900DACCB CRC64;
MSEHRHRSGD LHQQNKGFKG GKHDSKGAIK RRAQGKIETN GARQSIKNLA IVNNKDAMRQ
KHQKLVKSKK NELLERKRLG LPDQVAPRVV TIIKLSESCN TKKVKEMLLQ KFKLNINTGE
MEMDNEETLN NKNNNNDNFT TISLTSKVRM MLLECQTMAY DQVIEFCKLS DIILFVIDAN
QAKLNSEAER IFTIVKAQSV PTVIEIIQNL DQTPIKKRNE LKKSIQSVFH FHFPNEPKVL
PMDTNDECSQ VLRYIENIHV NEIIWRKVRP YMLIEKSSYI PETKVVTIDG FIRGNNLSAK
QIIHIPDYGD FQIEKIELID DPHIRKKSYY TNNNNNNSNN NNTGGGEMEQ DKKINILDKV
DQKDKDTLQT WNVPDPMDNE QALPTAEEMK EIEANKKKKL VPKGTSGYQS SWYLDNESDE
EEENFENEDL DMNQEEMGQD KEEEMGEEEE MGEEEEEEEE GQEELEEVKE SNKWKGIKHK
SQITDELLKD SDDEDDDENK EEQSEDEDED ERKQLQQDEI LYPDEVDTPG NVPSRIRFSK
FRGLKSFRSS PWDVKENLPI DYAKIFQFHS FNQSMRASIA ILDNAPAKPD MYVRIHLVNG
PKQLVERNTT AITTKPEVAV GLYRYENKIS LLHFSVEKHK SYEETVRSKE EVYFHFGWRK
FSTSPIYSIS SPNCDKQKFE KFLLPARNTM ATIYGPITYP PAPLLIFNGK DCNELVATGY
LSSVNPDRII CKRIILTGVI AKSISKKFVT VKDMFYYPED INWFKKVELY TKMGRVGHIK
EPLGTHGRMK CQFDGTMNQQ DTVCMNLYKR VYPKWIKDDS SLLKLE
