ID   TSR1_PONAB              Reviewed;         805 AA.
AC   Q5R434;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Pre-rRNA-processing protein TSR1 homolog;
GN   Name=TSR1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC       the nucleolus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Bms1-like GTPase family. TSR1 subfamily. {ECO:0000305}.
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DR   EMBL; CR861426; CAH93482.1; -; mRNA.
DR   RefSeq; NP_001127041.1; NM_001133569.1.
DR   AlphaFoldDB; Q5R434; -.
DR   SMR; Q5R434; -.
DR   STRING; 9601.ENSPPYP00000008779; -.
DR   GeneID; 100174068; -.
DR   KEGG; pon:100174068; -.
DR   CTD; 55720; -.
DR   eggNOG; KOG1980; Eukaryota.
DR   InParanoid; Q5R434; -.
DR   OrthoDB; 186926at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR012948; AARP2CN.
DR   InterPro; IPR039761; Bms1/Tsr1.
DR   InterPro; IPR007034; BMS1_TSR1_C.
DR   InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR   PANTHER; PTHR12858; PTHR12858; 1.
DR   Pfam; PF08142; AARP2CN; 1.
DR   Pfam; PF04950; RIBIOP_C; 1.
DR   SMART; SM00785; AARP2CN; 1.
DR   SMART; SM01362; DUF663; 1.
DR   PROSITE; PS51714; G_BMS1; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..805
FT                   /note="Pre-rRNA-processing protein TSR1 homolog"
FT                   /id="PRO_0000311276"
FT   DOMAIN          81..242
FT                   /note="Bms1-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01051"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   805 AA;  91869 MW;  86226EE1D5084AE5 CRC64;
     MAAHRPGTLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR VDQRHRASQL
     RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM QLLQDRDTGT VHLNELGNTQ
     SFMLLCPRLK HRWFFTSARP GDLHIVLDMA KVADTILFLL DPLEGWDSTG DYCLSCLFAQ
     GLPTYTLAVQ GISGLPLKKQ IDARKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK
     QQHLAFRDRR AYLFARAVDF VASEENNLVG TLKISGYVRG QTLNVNRLLH IVGHGDFQMK
     QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDTVDDMEEG LKVLMKADPD RQESLQAEVI
     PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY QAEWILDGGS QSGGEGDEYE
     YDDMEHEDFM EEESQDESSE EEEEEYETMT IGESVHDDLY DKKIDEEAEA KMLEKYKQER
     LEEMFPDEVD TPRDVAARIR FQKYRGLKSF RTSPWDPKEN LPQDYARIFQ FQNFTNTRKS
     IFKEVEEKEV EGAEVGCYVT LHVSEVPVSV VECFRQGTPL IAFSLLPHEQ KMSVLNMVVR
     RDPGNTEPVK AKEELIFHCG FRRFRASPLF SQHTAADKHK LQRFLTADMA LVATVYAPIT
     FPPASVLLFK QKSNGMHSLI ATGHLMSVDP DRMVIKRVVL SGHPLKMFTK MAVVRYMFFN
     REDVLWFKPV ELRTKWGRRG HIKEPLGTHG HMKCSFNGKL KSQDTVLMNL YKRVFPKWTY
     DPYVPEPVPW LKSEISSTVP QGGME