TSR1_SCHPO
ID TSR1_SCHPO Reviewed; 783 AA.
AC O13956;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ribosome biogenesis protein tsr1;
GN Name=tsr1; ORFNames=SPAC23H4.15;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for 40S ribosomal subunit synthesis. Required for
CC normal export of the pre-40S particles from the nucleus to the
CC cytoplasm (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Bms1-like GTPase family. TSR1 subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB11669.1; -; Genomic_DNA.
DR PIR; T38313; T38313.
DR RefSeq; NP_593391.1; NM_001018823.2.
DR AlphaFoldDB; O13956; -.
DR SMR; O13956; -.
DR BioGRID; 278272; 1.
DR STRING; 4896.SPAC23H4.15.1; -.
DR iPTMnet; O13956; -.
DR MaxQB; O13956; -.
DR PaxDb; O13956; -.
DR PRIDE; O13956; -.
DR EnsemblFungi; SPAC23H4.15.1; SPAC23H4.15.1:pep; SPAC23H4.15.
DR GeneID; 2541779; -.
DR KEGG; spo:SPAC23H4.15; -.
DR PomBase; SPAC23H4.15; tsr1.
DR VEuPathDB; FungiDB:SPAC23H4.15; -.
DR eggNOG; KOG1980; Eukaryota.
DR HOGENOM; CLU_009858_1_0_1; -.
DR InParanoid; O13956; -.
DR OMA; KTPHQQV; -.
DR PhylomeDB; O13956; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O13956; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; ISO:PomBase.
DR GO; GO:0005730; C:nucleolus; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR PANTHER; PTHR12858; PTHR12858; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..783
FT /note="Ribosome biogenesis protein tsr1"
FT /id="PRO_0000339127"
FT DOMAIN 80..243
FT /note="Bms1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01051"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 90126 MW; 67BDC6EC0AA7D346 CRC64;
MAHHHRSTFK AKKPFKSKHA SKSSLKEKYK NEVEPHRSGP KNIVHTSTKA DRRNTAKQIQ
LNKRTEVAMN NRIFGGKNGA PKVITIVPLC NNVDSWNVLT NLLRSIDPEA SLPKFDKDSI
SYSTTIDRFK QNLLFLLPKR EFYSLIDACK VSDYVIFVLS AVQEVDEFGE LIVRTTQGQG
ISSVLSMVHD LSEVDSLKTR NEVKKSLQSF MNFFFSDQER VFAADVSQDA LNVMRALCTS
HPRGIHWRDS RSYLLSQEIS YSNGNLLVRG IVRGKGLDPN RLIHIQGFGD FAINRIYEAP
QGIQNSRGIS MDEDTNLTGG LVELCSPTQE QDSLESLGPI IDDMDTDMDS EVGKEASRGV
RLDDFYYFDD EEEPVAVAKR VPKGTSTYQA TWIPDEDEES DQYSDVEDTE VIIEDQDNQE
ISNHVAEEKI DSDEEETIDD AKSEMFVDLS EEEEVRQYEE YRKKQKELQE ELEFPDEVEL
QPNELARERF KKYRGLRSLY TSQWDADEYD PNEPREWRQL FKFENYRNLK NKFLKQPFIG
EAKPGKAVYV ELRNVPIEIF EYYNKPWNLL VLYSLLQYEN KLTVSQFTAM QHSEYEEPIE
SKEELLLQIG PRRFMVRPLY SDPTASGASN NLQKYHRYLP PKQAVIASVI SPIVFGNVPI
IMFKKSSDNS LRLAATGSYV NCDTNSVIAK RAVLTGHPFK VHKKLVTIRY MFFNPEDVIW
FKPIQLFTKQ GRTGYIKEPL GTHGYFKATF NGKITVQDTV AMSLYKRMYP LPCELFKVTD
IDS
