ID   TSR1_XENLA              Reviewed;         815 AA.
AC   Q5XGY1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Pre-rRNA-processing protein TSR1 homolog;
GN   Name=tsr1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC       the nucleolus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Bms1-like GTPase family. TSR1 subfamily. {ECO:0000305}.
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DR   EMBL; BC084296; AAH84296.1; -; mRNA.
DR   RefSeq; NP_001088282.1; NM_001094813.1.
DR   AlphaFoldDB; Q5XGY1; -.
DR   SMR; Q5XGY1; -.
DR   BioGRID; 105195; 1.
DR   IntAct; Q5XGY1; 1.
DR   GeneID; 495115; -.
DR   KEGG; xla:495115; -.
DR   CTD; 495115; -.
DR   Xenbase; XB-GENE-5753645; tsr1.L.
DR   OrthoDB; 186926at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 495115; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR012948; AARP2CN.
DR   InterPro; IPR039761; Bms1/Tsr1.
DR   InterPro; IPR007034; BMS1_TSR1_C.
DR   InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR   PANTHER; PTHR12858; PTHR12858; 1.
DR   Pfam; PF08142; AARP2CN; 1.
DR   Pfam; PF04950; RIBIOP_C; 1.
DR   SMART; SM00785; AARP2CN; 1.
DR   SMART; SM01362; DUF663; 1.
DR   PROSITE; PS51714; G_BMS1; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..815
FT                   /note="Pre-rRNA-processing protein TSR1 homolog"
FT                   /id="PRO_0000311277"
FT   DOMAIN          87..247
FT                   /note="Bms1-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01051"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..459
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  93610 MW;  F4EC47178023A0A3 CRC64;
     MAAGEQQAAH RPGAYKQQNK PHKSGRHRGR GAQDRENKGR VAAKILGKKN KKDLRKLDRR
     HKANQIRRQR KDAVLAEKRS LGTKDGPPHL VIAISLHARA VKDDLFSLVQ NNEGDILHVN
     DQIKGLLALV CPKVKQRWCF IQANRDDLCS LLDLAKVADT LLFLLDPQEG WDSYGDYCLS
     CLFAQGLPSY VLAVQGMNYI PIKKRADIKK QLSKVIENRF TDAKLFQLDT EQEAAVLIRQ
     ISTQKQRHLA FRSRRSYMLA QRADFQPTDE SGLVGTLKLS GYVRGQELNV NRLVHIVGHG
     DFHMSQIDAP PDPYPLNPRV HKPKTKSGQD MEMSDEPATG SEMEQDIKVL MKADPSAQES
     LQCEVVPDPM EGEQTWPTEE ELKEAEDALK GTSKVVKKVP KGTSAYQAAW ILDDEGDGEE
     ESDDDDDEDM EEDAEDAMDD AYSEEEDGSG NEEAEESETL TIPDSTRDDK YDENVDEQEE
     EQMLEKYKLQ RQDEVFPDEV DTPRDQIARI RFQKYRGLKS FRTSPWDVKE NLPRDYARIF
     QFHDFFRTRK RVFKEEEEKD EGAMVGWYVT VHISAVPVSV MEHFKHGLPL VLCSLLPHEQ
     KMSVMNMLVR RHPGNNEPIK AKEELIFHCG FRRFRASPLF SQHSSADKHK SERFLRSDTS
     VVVTVYAPIT FPPASVLVFK QRYNGMQDLV ATGSLLNVNP DRIVIKRIVL SGHPFKIMKR
     TAVVRYMFFN REDVLWFKPV ELRTKWGRRG HIKEPLGTHG HMKCHFDGQL KSQDTVLMNL
     YKRVYPKWTF DPYVPRPVTW VKNENTVDIT EVEMD