ID   TSR2_DANRE              Reviewed;         181 AA.
AC   Q3KRG3; Q6TH19;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Pre-rRNA-processing protein TSR2 homolog;
GN   Name=tsr2; Synonyms=dt1p1a10l; ORFNames=zgc:109784;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in 20S pre-rRNA processing. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TSR2 family. {ECO:0000305}.
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DR   EMBL; AY398337; AAQ97770.1; -; mRNA.
DR   EMBL; BC066714; AAH66714.1; -; mRNA.
DR   AlphaFoldDB; Q3KRG3; -.
DR   SMR; Q3KRG3; -.
DR   STRING; 7955.ENSDARP00000026184; -.
DR   PaxDb; Q3KRG3; -.
DR   ZFIN; ZDB-GENE-021231-2; tsr2.
DR   eggNOG; KOG4032; Eukaryota.
DR   InParanoid; Q3KRG3; -.
DR   PRO; PR:Q3KRG3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   InterPro; IPR019398; Pre-rRNA_process_TSR2.
DR   PANTHER; PTHR21250; PTHR21250; 1.
DR   Pfam; PF10273; WGG; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; rRNA processing.
FT   CHAIN           1..181
FT                   /note="Pre-rRNA-processing protein TSR2 homolog"
FT                   /id="PRO_0000285589"
FT   REGION          118..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        58
FT                   /note="G -> D (in Ref. 1; AAQ97770)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        134
FT                   /note="Q -> QD (in Ref. 1; AAQ97770)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   181 AA;  19992 MW;  D0AD838B5C1822B7 CRC64;
     MAPLSSSTRE VFSEAVRAVL ETWPVLQIAV DNGFGGAFSQ QKAEWMVDAL QQYFTDNGDL
     QPDEVEDFIS ELMNNEFDTV VDDGSLPQVA QQVCGMFQQC EQGRLAEVRE QILKLNQKKT
     SSGRAKATPA QTPQDDDDDD EEEAMDCEGG SAGASVSSTA VNDLHHEEEE DDGWTVVRRK
     K