TSR2_MOUSE
ID TSR2_MOUSE Reviewed; 191 AA.
AC Q8C8T8; A2ALP6; Q8R3M9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Pre-rRNA-processing protein TSR2 homolog;
GN Name=Tsr2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in 20S pre-rRNA processing. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TSR2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM14872.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK044504; BAC31955.1; -; mRNA.
DR EMBL; AL805937; CAM14872.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC025008; AAH25008.1; -; mRNA.
DR EMBL; BC049668; AAH49668.1; -; mRNA.
DR RefSeq; NP_780355.2; NM_175146.4.
DR AlphaFoldDB; Q8C8T8; -.
DR SMR; Q8C8T8; -.
DR BioGRID; 213486; 15.
DR STRING; 10090.ENSMUSP00000108303; -.
DR iPTMnet; Q8C8T8; -.
DR PhosphoSitePlus; Q8C8T8; -.
DR EPD; Q8C8T8; -.
DR MaxQB; Q8C8T8; -.
DR PaxDb; Q8C8T8; -.
DR PeptideAtlas; Q8C8T8; -.
DR PRIDE; Q8C8T8; -.
DR ProteomicsDB; 298000; -.
DR TopDownProteomics; Q8C8T8; -.
DR DNASU; 69499; -.
DR GeneID; 69499; -.
DR KEGG; mmu:69499; -.
DR UCSC; uc009uoy.2; mouse.
DR CTD; 90121; -.
DR MGI; MGI:1916749; Tsr2.
DR eggNOG; KOG4032; Eukaryota.
DR InParanoid; Q8C8T8; -.
DR OMA; IEIMDYT; -.
DR PhylomeDB; Q8C8T8; -.
DR TreeFam; TF314018; -.
DR BioGRID-ORCS; 69499; 27 hits in 75 CRISPR screens.
DR PRO; PR:Q8C8T8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8C8T8; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR InterPro; IPR019398; Pre-rRNA_process_TSR2.
DR PANTHER; PTHR21250; PTHR21250; 1.
DR Pfam; PF10273; WGG; 1.
PE 1: Evidence at protein level;
KW Reference proteome; rRNA processing.
FT CHAIN 1..191
FT /note="Pre-rRNA-processing protein TSR2 homolog"
FT /id="PRO_0000285588"
FT REGION 140..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 191 AA; 20891 MW; 31A783CB6D049C6E CRC64;
MAGAAEDVRV LFGAAVRAAL EAWPALQIAV ENGFGGVHSQ EKAEWLGGAV EDYFIANADL
ELEEIEDFLG ELMTTEFDTV VEDGSLPQVS QQLQTMFHHF QKGDGAALQE MTSQINQKKC
KVTATPLMTA KETDVAEDDV DSVEEMEVTA TNDGATTDEV CPQPQPSDPD TQTIKEEDIV
EDGWTIVRRK K
