ID   TSR2_SCHPO              Reviewed;         179 AA.
AC   Q9UUA9;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Pre-rRNA-processing protein tsr2;
GN   Name=tsr2; ORFNames=SPBC409.15;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for 20S pre-rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the TSR2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB52617.1; -; Genomic_DNA.
DR   PIR; T40442; T40442.
DR   RefSeq; NP_595465.1; NM_001021375.2.
DR   AlphaFoldDB; Q9UUA9; -.
DR   SMR; Q9UUA9; -.
DR   BioGRID; 277332; 5.
DR   STRING; 4896.SPBC409.15.1; -.
DR   iPTMnet; Q9UUA9; -.
DR   MaxQB; Q9UUA9; -.
DR   PaxDb; Q9UUA9; -.
DR   PRIDE; Q9UUA9; -.
DR   EnsemblFungi; SPBC409.15.1; SPBC409.15.1:pep; SPBC409.15.
DR   GeneID; 2540813; -.
DR   KEGG; spo:SPBC409.15; -.
DR   PomBase; SPBC409.15; tsr2.
DR   VEuPathDB; FungiDB:SPBC409.15; -.
DR   eggNOG; KOG4032; Eukaryota.
DR   HOGENOM; CLU_074896_0_2_1; -.
DR   InParanoid; Q9UUA9; -.
DR   OMA; HRVIFAP; -.
DR   PhylomeDB; Q9UUA9; -.
DR   PRO; PR:Q9UUA9; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   InterPro; IPR019398; Pre-rRNA_process_TSR2.
DR   PANTHER; PTHR21250; PTHR21250; 1.
DR   Pfam; PF10273; WGG; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..179
FT                   /note="Pre-rRNA-processing protein tsr2"
FT                   /id="PRO_0000362996"
FT   REGION          123..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  20509 MW;  7B9274DFD6E1E158 CRC64;
     MFDDPSKRLT YFEYAVGVLL CSWPVMKQAV EEEWADVDTA DKRDWMAGVL VDYITVTSDV
     EAWDVEELIL QVLQDEFNVG SIEDDSPYIL AQDLVNVWKA ACEDNYEPIR EIHERLGKQL
     LEKEEGKEKT REESNPPVLV EDETIVDAED GGAAQNQQEK QQGPIVDDDG FTVVQKRRR