ID   C42S1_PONAB             Reviewed;          79 AA.
AC   Q5RDD6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=CDC42 small effector protein 1;
GN   Name=CDC42SE1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in the organization of the actin
CC       cytoskeleton by acting downstream of CDC42, inducing actin filament
CC       assembly. Alters CDC42-induced cell shape changes. In activated T-
CC       cells, may play a role in CDC42-mediated F-actin accumulation at the
CC       immunological synapse. May play a role in early contractile events in
CC       phagocytosis in macrophages (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDC42 (in GTP-bound form). Interacts weakly
CC       with RAC1 and not at all with RHOA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC   -!- DOMAIN: The CRIB domain mediates interaction with CDC42. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC42SE/SPEC family. {ECO:0000305}.
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DR   EMBL; CR857977; CAH90221.1; -; mRNA.
DR   RefSeq; NP_001125089.1; NM_001131617.1.
DR   AlphaFoldDB; Q5RDD6; -.
DR   STRING; 9601.ENSPPYP00000001028; -.
DR   GeneID; 100171971; -.
DR   KEGG; pon:100171971; -.
DR   CTD; 56882; -.
DR   eggNOG; ENOG502S499; Eukaryota.
DR   InParanoid; Q5RDD6; -.
DR   OrthoDB; 1646014at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   Gene3D; 3.90.810.10; -; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR039056; SPEC.
DR   PANTHER; PTHR13502; PTHR13502; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell shape; Cytoplasm; Cytoskeleton; Lipoprotein; Membrane;
KW   Palmitate; Phagocytosis; Reference proteome.
FT   CHAIN           1..79
FT                   /note="CDC42 small effector protein 1"
FT                   /id="PRO_0000334631"
FT   DOMAIN          30..43
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT   REGION          48..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           10
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           11
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8953 MW;  D1C1C5F2D320F65B CRC64;
     MSEFWHKLGC CVVEKPQPKK RRRRIDRTMI GEPMNFVHLT HIGSGEMGAG DGLAMTGAVQ
     EQMRSKGNRD RPWSNSRGL