ID   C42S1_RAT               Reviewed;          79 AA.
AC   Q5BJM7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=CDC42 small effector protein 1;
GN   Name=Cdc42se1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably involved in the organization of the actin
CC       cytoskeleton by acting downstream of CDC42, inducing actin filament
CC       assembly. Alters CDC42-induced cell shape changes. In activated T-
CC       cells, may play a role in CDC42-mediated F-actin accumulation at the
CC       immunological synapse. May play a role in early contractile events in
CC       phagocytosis in macrophages (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDC42 (in GTP-bound form). Interacts weakly
CC       with RAC1 and not at all with RHOA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC   -!- DOMAIN: The CRIB domain mediates interaction with CDC42. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC42SE/SPEC family. {ECO:0000305}.
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DR   EMBL; BC091418; AAH91418.1; -; mRNA.
DR   RefSeq; NP_001034133.1; NM_001039044.1.
DR   AlphaFoldDB; Q5BJM7; -.
DR   STRING; 10116.ENSRNOP00000034839; -.
DR   PaxDb; Q5BJM7; -.
DR   GeneID; 499672; -.
DR   KEGG; rno:499672; -.
DR   UCSC; RGD:1561700; rat.
DR   CTD; 56882; -.
DR   RGD; 1561700; Cdc42se1.
DR   eggNOG; ENOG502S499; Eukaryota.
DR   HOGENOM; CLU_173417_1_0_1; -.
DR   InParanoid; Q5BJM7; -.
DR   OMA; DRPWNNS; -.
DR   OrthoDB; 1646014at2759; -.
DR   PhylomeDB; Q5BJM7; -.
DR   TreeFam; TF323815; -.
DR   PRO; PR:Q5BJM7; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000060538; Expressed in spleen and 20 other tissues.
DR   Genevisible; Q5BJM7; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   Gene3D; 3.90.810.10; -; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR039056; SPEC.
DR   PANTHER; PTHR13502; PTHR13502; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell shape; Cytoplasm; Cytoskeleton; Lipoprotein; Membrane;
KW   Palmitate; Phagocytosis; Reference proteome.
FT   CHAIN           1..79
FT                   /note="CDC42 small effector protein 1"
FT                   /id="PRO_0000334632"
FT   DOMAIN          30..43
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT   REGION          48..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           10
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           11
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8967 MW;  D1C465F2D320F65B CRC64;
     MSEFWHKLGC CVVEKPQPKK RRRRIDRTMI GEPMNFVHLT HIGSGEMGAG DGLAMTGAVQ
     EQMRSKGNRD RPWSNSRAL