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TSR4_YEAST
ID   TSR4_YEAST              Reviewed;         408 AA.
AC   P25040; D6W243;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=20S rRNA accumulation protein 4;
GN   Name=TSR4; OrderedLocusNames=YOL022C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 284-408.
RX   PubMed=1935960; DOI=10.1111/j.1432-1033.1991.tb16325.x;
RA   Vambutas A., Ackerman S.H., Tzagoloff A.;
RT   "Mitochondrial translational-initiation and elongation factors in
RT   Saccharomyces cerevisiae.";
RL   Eur. J. Biochem. 201:643-652(1991).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [8]
RP   FUNCTION.
RX   PubMed=19806183; DOI=10.1371/journal.pbio.1000213;
RA   Li Z., Lee I., Moradi E., Hung N.J., Johnson A.W., Marcotte E.M.;
RT   "Rational extension of the ribosome biogenesis pathway using network-guided
RT   genetics.";
RL   PLoS Biol. 7:E1000213-E1000213(2009).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- FUNCTION: Required for processing of the 20S pre-rRNA at site D to
CC       generate mature 18S rRNA. {ECO:0000269|PubMed:19806183}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the TSR4 family. {ECO:0000305}.
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DR   EMBL; Z74764; CAA99022.1; -; Genomic_DNA.
DR   EMBL; AY558025; AAS56351.1; -; Genomic_DNA.
DR   EMBL; X58379; CAA41269.1; -; Genomic_DNA.
DR   EMBL; BK006948; DAA10759.1; -; Genomic_DNA.
DR   PIR; S66705; S66705.
DR   RefSeq; NP_014620.1; NM_001183276.2.
DR   AlphaFoldDB; P25040; -.
DR   BioGRID; 34379; 62.
DR   DIP; DIP-5322N; -.
DR   IntAct; P25040; 13.
DR   MINT; P25040; -.
DR   STRING; 4932.YOL022C; -.
DR   iPTMnet; P25040; -.
DR   MaxQB; P25040; -.
DR   PaxDb; P25040; -.
DR   PRIDE; P25040; -.
DR   EnsemblFungi; YOL022C_mRNA; YOL022C; YOL022C.
DR   GeneID; 854136; -.
DR   KEGG; sce:YOL022C; -.
DR   SGD; S000005382; TSR4.
DR   VEuPathDB; FungiDB:YOL022C; -.
DR   eggNOG; KOG2061; Eukaryota.
DR   GeneTree; ENSGT00940000156603; -.
DR   HOGENOM; CLU_031771_0_0_1; -.
DR   InParanoid; P25040; -.
DR   OMA; LMPKMIL; -.
DR   BioCyc; YEAST:G3O-33438-MON; -.
DR   PRO; PR:P25040; -.
DR   Proteomes; UP000002311; Chromosome XV.
DR   RNAct; P25040; protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0051082; F:unfolded protein binding; IDA:SGD.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IMP:SGD.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IMP:SGD.
DR   InterPro; IPR007320; PDCD2_C.
DR   Pfam; PF04194; PDCD2_C; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; rRNA processing.
FT   CHAIN           1..408
FT                   /note="20S rRNA accumulation protein 4"
FT                   /id="PRO_0000203487"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  45994 MW;  B7F8642CF19FC11B CRC64;
     MSKIEELPPS DTDDHSYSSK PGDVFLAFVD APVKETDDIL VEDSFIGGEP KWLHPDSEPP
     AELLKCGACK SADNMKLLLQ AFSPLDDEQM SAIQQRLGIN NMSYINPQDD RVLYVFLCTE
     CQRKGNSVRC IRGVKKNKNV DSLSEKMAST SLEKDFQINP FDLSNNSDSK CNAFSSNPFG
     GANANPFGAD SINSNISQSK DEGKKKESAT VSAKTARKLH DLQKDKEYDG NKCFKSCLLY
     VEEETFKNKK PAHLQLPKNL KIDKEALDLT GDEDLEKDPI KLDPRTEKLS KFLDDDTFQK
     FQEVVGYNPL QVLRYDLGGK PLLYAETKVD ILSTVPRPGY NPSSQRIFEM QLMPKMIFDL
     EEVVSVDNGM EWGTILVFTD VENYMPEFDE HGVGYVEECV KVQWESRT
 
 
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