ID   TSSA1_PSEAE             Reviewed;         344 AA.
AC   Q9I750;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Type VI secretion system component TssA1 {ECO:0000303|PubMed:27288401};
GN   Name=tssA1 {ECO:0000303|PubMed:27288401}; OrderedLocusNames=PA0082;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBUNIT, AND INTERACTION WITH TSSB1; TSSC1;
RP   TSSF1 AND TSSK1.
RX   PubMed=27288401; DOI=10.15252/embj.201694024;
RA   Planamente S., Salih O., Manoli E., Albesa-Jove D., Freemont P.S.,
RA   Filloux A.;
RT   "TssA forms a gp6-like ring attached to the type VI secretion sheath.";
RL   EMBO J. 35:1613-1627(2016).
CC   -!- FUNCTION: Core component of the H1 type VI (H1-T6SS) secretion system
CC       that plays a role in the release of toxins targeting both eukaryotic
CC       and prokaryotic species. Forms a dodecameric ring-shaped structure
CC       located at one end of the T6SS sheath. May properly attach the pre-
CC       assembled sheath onto the baseplate and/or stabilize the sheaths
CC       tubular structure. {ECO:0000269|PubMed:27288401}.
CC   -!- SUBUNIT: Homododecamer. Interacts with TssB1 and TssC1. Interacts with
CC       TssK1 and TssF1. {ECO:0000269|PubMed:27288401}.
CC   -!- DISRUPTION PHENOTYPE: Deletion abolishes the secretion of Hcp1, Tse3
CC       and VgrG proteins, all markers of T6SS activity.
CC       {ECO:0000269|PubMed:27288401}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG03472.1; -; Genomic_DNA.
DR   PIR; G83634; G83634.
DR   RefSeq; NP_248772.1; NC_002516.2.
DR   RefSeq; WP_003115054.1; NZ_QZGE01000015.1.
DR   AlphaFoldDB; Q9I750; -.
DR   SMR; Q9I750; -.
DR   STRING; 287.DR97_3039; -.
DR   PaxDb; Q9I750; -.
DR   PRIDE; Q9I750; -.
DR   DNASU; 879402; -.
DR   EnsemblBacteria; AAG03472; AAG03472; PA0082.
DR   GeneID; 879402; -.
DR   KEGG; pae:PA0082; -.
DR   PATRIC; fig|208964.12.peg.86; -.
DR   PseudoCAP; PA0082; -.
DR   HOGENOM; CLU_060104_0_0_6; -.
DR   InParanoid; Q9I750; -.
DR   OMA; KPEQQFG; -.
DR   PhylomeDB; Q9I750; -.
DR   BioCyc; PAER208964:G1FZ6-84-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0033104; C:type VI protein secretion system complex; IDA:PseudoCAP.
DR   InterPro; IPR010657; ImpA_N.
DR   InterPro; IPR017740; TssA-like.
DR   PANTHER; PTHR37951; PTHR37951; 1.
DR   Pfam; PF06812; ImpA_N; 1.
DR   TIGRFAMs; TIGR03363; VI_chp_8; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..344
FT                   /note="Type VI secretion system component TssA1"
FT                   /id="PRO_0000449261"
SQ   SEQUENCE   344 AA;  36679 MW;  3321BAC4C8DB025D CRC64;
     MLDVPVLLAA VSPDSPCGDD LEYDAAFLEL ERIAQGQPER QMGDAVLPAE PPEWPRVRAL
     ASELFGRSKD LRVANLLLQS NVALDGLDGL ADGLLLVREL LGQYWDGVYP LLDADDDNDP
     TFRINALTGL VAEPLLQLVW AIPLVRSRAF GPVNLRAALN AAGLQRFASE TLSPEQIAGA
     FADADADALA ATRRALDGAQ EHALAIESGV AERVGSAQGL DLGPLRQLLR QALQVFDLYG
     PQGAGESLAP GAEAVADEQV GAAPVAAVAA PAPRASGEIA NREDVLRQLD RLLEYYVRHE
     PSSPVPVLLK RAKTLVTADF AEIVRNLIPD GISQFETLRG PESE