TSSC4_MOUSE
ID TSSC4_MOUSE Reviewed; 317 AA.
AC Q9JHE7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein TSSC4;
GN Name=Tssc4; ORFNames=MNCb-3063;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10907850; DOI=10.1093/dnares/7.3.195;
RA Yatsuki H., Watanabe H., Hattori M., Joh K., Soejima H., Komoda H., Xin Z.,
RA Zhu X., Higashimoto K., Nishimura M., Kuratomi S., Sasaki H., Sakaki Y.,
RA Mukai T.;
RT "Sequence-based structural features between Kvlqt1 and Tapa1 on mouse
RT chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region
RT on human 11p15.5: long-stretches of unusually well conserved intronic
RT sequences of kvlqt1 between mouse and human.";
RL DNA Res. 7:195-206(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv, and C57BL/6J;
RX PubMed=10915772; DOI=10.1093/hmg/9.12.1829;
RA Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K.,
RA Reinhardt R., Reik W., Walter J.;
RT "Sequence conservation and variability of imprinting in the Beckwith-
RT Wiedemann syndrome gene cluster in human and mouse.";
RL Hum. Mol. Genet. 9:1829-1841(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-64; SER-92 AND
RP THR-124, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Tssc4-1;
CC IsoId=Q9JHE7-1; Sequence=Displayed;
CC Name=2; Synonyms=Tssc4-2;
CC IsoId=Q9JHE7-2; Sequence=VSP_016562, VSP_016563;
CC -!- TISSUE SPECIFICITY: Expressed in placenta. Widely expressed in embryo
CC and newborn. {ECO:0000269|PubMed:10915772}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo at 12.5 dpc and 16.5 dpc.
CC {ECO:0000269|PubMed:10915772}.
CC -!- SIMILARITY: Belongs to the TSSC4 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB038011; BAA96876.1; -; mRNA.
DR EMBL; AJ251835; CAB94775.1; -; Genomic_DNA.
DR EMBL; AJ279796; CAB94724.1; -; mRNA.
DR EMBL; AB041597; BAA95080.1; -; mRNA.
DR CCDS; CCDS40195.1; -. [Q9JHE7-1]
DR CCDS; CCDS40196.1; -. [Q9JHE7-2]
DR RefSeq; NP_001108557.1; NM_001115085.1. [Q9JHE7-1]
DR RefSeq; NP_064681.1; NM_020285.2. [Q9JHE7-1]
DR AlphaFoldDB; Q9JHE7; -.
DR BioGRID; 208191; 1.
DR IntAct; Q9JHE7; 1.
DR MINT; Q9JHE7; -.
DR STRING; 10090.ENSMUSP00000056582; -.
DR iPTMnet; Q9JHE7; -.
DR PhosphoSitePlus; Q9JHE7; -.
DR EPD; Q9JHE7; -.
DR jPOST; Q9JHE7; -.
DR MaxQB; Q9JHE7; -.
DR PaxDb; Q9JHE7; -.
DR PeptideAtlas; Q9JHE7; -.
DR PRIDE; Q9JHE7; -.
DR ProteomicsDB; 297668; -. [Q9JHE7-1]
DR ProteomicsDB; 297669; -. [Q9JHE7-2]
DR Antibodypedia; 42107; 75 antibodies from 18 providers.
DR DNASU; 56844; -.
DR Ensembl; ENSMUST00000060433; ENSMUSP00000056582; ENSMUSG00000045752. [Q9JHE7-1]
DR Ensembl; ENSMUST00000105920; ENSMUSP00000101540; ENSMUSG00000045752. [Q9JHE7-2]
DR Ensembl; ENSMUST00000177841; ENSMUSP00000137399; ENSMUSG00000045752. [Q9JHE7-1]
DR Ensembl; ENSMUST00000208779; ENSMUSP00000146914; ENSMUSG00000045752. [Q9JHE7-2]
DR GeneID; 56844; -.
DR KEGG; mmu:56844; -.
DR UCSC; uc009kow.1; mouse. [Q9JHE7-1]
DR CTD; 10078; -.
DR MGI; MGI:1861712; Tssc4.
DR VEuPathDB; HostDB:ENSMUSG00000045752; -.
DR eggNOG; ENOG502S07M; Eukaryota.
DR GeneTree; ENSGT00390000011846; -.
DR HOGENOM; CLU_077569_0_0_1; -.
DR InParanoid; Q9JHE7; -.
DR OMA; HFRNKGS; -.
DR OrthoDB; 1538986at2759; -.
DR PhylomeDB; Q9JHE7; -.
DR TreeFam; TF335741; -.
DR BioGRID-ORCS; 56844; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tssc4; mouse.
DR PRO; PR:Q9JHE7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JHE7; protein.
DR Bgee; ENSMUSG00000045752; Expressed in saccule of membranous labyrinth and 250 other tissues.
DR ExpressionAtlas; Q9JHE7; baseline and differential.
DR Genevisible; Q9JHE7; MM.
DR InterPro; IPR029338; TSSC4.
DR PANTHER; PTHR13445; PTHR13445; 1.
DR Pfam; PF15264; TSSC4; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..317
FT /note="Protein TSSC4"
FT /id="PRO_0000076361"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y5U2"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 124
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 214
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y5U2"
FT VAR_SEQ 113..114
FT /note="VS -> AP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10915772"
FT /id="VSP_016562"
FT VAR_SEQ 115..317
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10915772"
FT /id="VSP_016563"
SQ SEQUENCE 317 AA; 33569 MW; F0BC4EAEA7709342 CRC64;
MAETEAGLEA DEPTEDDTLP SDTVSLSDSD SDLSLPSGVE VQVLSPERLS EEGQEDSGPE
DPPSPPTGTL TTAVQPFHLR GMSSTFSQRS HSIFDCLESA ARQAPCSAPQ TSVSDNGSFR
RPVTPPSQTP ARGLSRVHGN TGPTRVLPVP DYVSHPERWT KYSLEDVSEA SEQSNRDAAL
AFLSSRSQVS HTDYVPSFNQ DPSSCGEGRV VFTKPVRDSE ARAERKRVLK KGVGSGAGGE
AAVELAHLAG PEAEEWSGHQ GQPEVVVPSE AAHPESSSGP IGVKAVGFHG SKKRSRDHFR
NRDGNPGGPG SERGPSV
