ID   C42S2_DANRE             Reviewed;          85 AA.
AC   A9JR56;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=CDC42 small effector protein 2;
GN   Name=cdc42se2; ORFNames=zgc:172116;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in the organization of the actin
CC       cytoskeleton by acting downstream of CDC42, inducing actin filament
CC       assembly. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC42SE/SPEC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC154538; AAI54539.1; -; mRNA.
DR   RefSeq; NP_001153307.1; NM_001159835.2.
DR   RefSeq; XP_005155605.1; XM_005155548.3.
DR   RefSeq; XP_009303378.1; XM_009305103.2.
DR   AlphaFoldDB; A9JR56; -.
DR   STRING; 7955.ENSDARP00000123282; -.
DR   PaxDb; A9JR56; -.
DR   Ensembl; ENSDART00000142507; ENSDARP00000123282; ENSDARG00000094577.
DR   Ensembl; ENSDART00000165018; ENSDARP00000142015; ENSDARG00000094577.
DR   Ensembl; ENSDART00000184155; ENSDARP00000156580; ENSDARG00000113403.
DR   GeneID; 794234; -.
DR   KEGG; dre:794234; -.
DR   CTD; 56990; -.
DR   ZFIN; ZDB-GENE-080204-45; cdc42se2.
DR   eggNOG; ENOG502S22R; Eukaryota.
DR   GeneTree; ENSGT00940000158245; -.
DR   HOGENOM; CLU_173417_1_0_1; -.
DR   InParanoid; A9JR56; -.
DR   OMA; IGVPTNF; -.
DR   OrthoDB; 1646014at2759; -.
DR   PhylomeDB; A9JR56; -.
DR   TreeFam; TF323815; -.
DR   Reactome; R-DRE-9013148; CDC42 GTPase cycle.
DR   PRO; PR:A9JR56; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000094577; Expressed in retina and 10 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0009966; P:regulation of signal transduction; ISS:UniProtKB.
DR   Gene3D; 3.90.810.10; -; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR039056; SPEC.
DR   PANTHER; PTHR13502; PTHR13502; 1.
DR   Pfam; PF00786; PBD; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell shape; Cytoplasm; Cytoskeleton; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome.
FT   CHAIN           1..85
FT                   /note="CDC42 small effector protein 2"
FT                   /id="PRO_0000334643"
FT   DOMAIN          29..42
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT   LIPID           10
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           11
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  9426 MW;  74E211DFCC043E17 CRC64;
     MSEFWLCFNC CIAEQPQPKR RRRIDRSMIG EPTNFVHTAH VGSGDLFTGM NSVNSIQNQM
     QSKGGYGGEA MSVNVQMQLV DTKAG