ID   TSTA_DICDI              Reviewed;        1408 AA.
AC   Q54NU8;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=TSET complex member tstA {ECO:0000305};
DE   AltName: Full=Protein TPLATE {ECO:0000303|PubMed:24867644};
GN   Name=tstA {ECO:0000303|PubMed:24867644};
GN   ORFNames=DDB0186293 {ECO:0000312|EMBL:EAL64952.1};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION IN THE TSET COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=24867644; DOI=10.7554/elife.02866;
RA   Hirst J., Schlacht A., Norcott J.P., Traynor D., Bloomfield G.,
RA   Antrobus R., Kay R.R., Dacks J.B., Robinson M.S.;
RT   "Characterization of TSET, an ancient and widespread membrane trafficking
RT   complex.";
RL   Elife 3:E02866-E02866(2014).
CC   -!- SUBUNIT: Component of the TSET complex, a heterohexamer composed of
CC       tstA, tstB, tstC, tstD, tstE and tstF, which may act in plasma membrane
CC       turnover. tstA, tstB, tstC and tstD are likely to be the core complex
CC       members with tstE and tstF acting as associated scaffold proteins.
CC       {ECO:0000269|PubMed:24867644}.
CC   -!- SIMILARITY: Belongs to the TPLATE family. {ECO:0000305}.
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DR   EMBL; AAFI01000116; EAL64952.1; -; Genomic_DNA.
DR   RefSeq; XP_639969.1; XM_634877.1.
DR   AlphaFoldDB; Q54NU8; -.
DR   SMR; Q54NU8; -.
DR   STRING; 44689.DDB0304556; -.
DR   PaxDb; Q54NU8; -.
DR   GeneID; 8624880; -.
DR   KEGG; ddi:DDB_G0284977; -.
DR   dictyBase; DDB_G0284977; tstA.
DR   eggNOG; ENOG502RF61; Eukaryota.
DR   HOGENOM; CLU_253872_0_0_1; -.
DR   InParanoid; Q54NU8; -.
DR   OMA; PESRWAG; -.
DR   PRO; PR:Q54NU8; -.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR037501; TPLATE.
DR   PANTHER; PTHR36029; PTHR36029; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
FT   CHAIN           1..1408
FT                   /note="TSET complex member tstA"
FT                   /id="PRO_0000445758"
FT   REGION          259..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          998..1055
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1091..1139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1408 AA;  156889 MW;  D87C38FE0AFCAC1C CRC64;
     MEIEIYDELN SSDSLKQING LSKLNQFWIN QGRDPTLFFT SIIKLISETD NKTTRILCYS
     ILKSCKCTPS DWSLAIPLLV KDLNSDDNEV VISILKTLPH ISSIFTELLM MGNADFGPLV
     RHGNPSVRKT ALDTLTSLLF YRKSILQSYK SFVSTGWELI VDRILEEPIP MVYQSSFSAI
     SSLFSEISRS VSHSDELDNS VQKRQVLSYY ADWISLKLID HFDLLLNRAQ HIDINQRHST
     VNTLTYLVDT ISRSSGTPFW PTSFDNNNNN NNNQQINNNN NNNNNNNNNN NNNNNNNNNN
     NNNNNQNNLI NGISSMNLSS ITGTTTTTTT TGNSPITSPT SPTSIIANTA SSNKTKQISS
     PQNIVSILVE YFLSQLDSSN DSLVFAVGKA ILDLLLTQQN QHNENWINPV LTAFIGLLRR
     EGVSLNPLPI LLAIMSVLPM LGDDLLFCTL SRIFPSIKSI TDSNQRVSYL IRTFELIIDR
     HVTSSGKSSL FTPLMTTDCL LMAFQDESSS FREEIIVSMV ASHHNILSKY IEIESEKNSN
     NNNSSSGNSG GGSGGSVKFS TSGNLFYLHQ AALNISEVCL KCITWQSERI SAIEYCIRFV
     DWLCRVTLSS SSSSNNSGNG SESQYGIKLI SLLRSDLLDQ INKIPSDYIC LQAVFLICTH
     LLRSPTNKVY EQSDAGLLIS LLRRRFLFLD NQPKFTQYNG NIRDMIMGVS QFGRVSPASL
     HSLSGYWLGA LECLYLMGLH IPSVEATVQR TLEEILATYP HNKSVYSRAR FIRRMLFSST
     SSALDAQSLG KYSTIRNLNS FTNYTIDFSY CIPIEQLEAS NSLHSISDIF AYECKKAITG
     LVGVHYGSSI RDKSSRDVTL ISGASDPVWI EVSHTTHPTL NTITLHVQVT NVIHFSIKNV
     NIMIGLSGHL DFPYPQTNCK HNIPKLLPEK SYSFEVPLNV SSLDYNLVTF KLTFNQPSGL
     CESENNINLN NIHTKINNYQ QSSDQLLVQS IQQQQQQQQS SSQQQSQQSQ QQQYQPQPIS
     SVNSGLSSYS LNSNNSGSLN SSANSHSIST SAVGSPGTAS FISSSLLSNA QSSSPTTSSP
     LSNVINQNII SSSSSSSSNA NQITSTTTPS STTNSNNNTT SSSSSTNPNP NPNSHTNLNS
     IVGSGINQPI INNQIIQSLS ITTNNPSANI IQFSPIEIRC SDYIFDWNQF LIPFKYNKHQ
     FIQQWPRFEA VFSIDVVFEG FVSVASIFDC LSALPLHNVL NSEFGNSNFH FAFSSSTWFN
     EQFCFTISGM EKCLSFPEDY SIYYTSPNGQ SLPKYKVYHA RFEFRSSSSS LLASFESIID
     QWINKLPRPT SDQFIARLLA PDEKSLFSIT NITQDYQAPK NHQSLANTPL SNIVDDEIAL
     LNQWKDFKKS QEQTKKLFSQ LALDQDFY