ID   TSTC_DICDI              Reviewed;         563 AA.
AC   Q54E64;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=TSET complex member tstC {ECO:0000305};
DE   AltName: Full=Protein TCUP {ECO:0000303|PubMed:24867644};
GN   Name=tstC {ECO:0000303|PubMed:24867644};
GN   ORFNames=DDB0191600 {ECO:0000312|EMBL:EAL61580.1};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION IN THE TSET COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=24867644; DOI=10.7554/elife.02866;
RA   Hirst J., Schlacht A., Norcott J.P., Traynor D., Bloomfield G.,
RA   Antrobus R., Kay R.R., Dacks J.B., Robinson M.S.;
RT   "Characterization of TSET, an ancient and widespread membrane trafficking
RT   complex.";
RL   Elife 3:E02866-E02866(2014).
CC   -!- SUBUNIT: Component of the TSET complex, a heterohexamer composed of
CC       tstA, tstB, tstC, tstD, tstE and tstF, which may act in plasma membrane
CC       turnover. tstA, tstB, tstC and tstD are likely to be the core complex
CC       members with tstE and tstF acting as associated scaffold proteins.
CC       {ECO:0000269|PubMed:24867644}.
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DR   EMBL; AAFI01000260; EAL61580.1; -; Genomic_DNA.
DR   RefSeq; XP_629998.1; XM_629996.1.
DR   AlphaFoldDB; Q54E64; -.
DR   STRING; 44689.DDB0191600; -.
DR   PaxDb; Q54E64; -.
DR   GeneID; 8628328; -.
DR   KEGG; ddi:DDB_G0291768; -.
DR   dictyBase; DDB_G0291768; tstC.
DR   HOGENOM; CLU_484347_0_0_1; -.
DR   PRO; PR:Q54E64; -.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   1: Evidence at protein level;
FT   CHAIN           1..563
FT                   /note="TSET complex member tstC"
FT                   /id="PRO_0000445760"
FT   REGION          146..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  61264 MW;  235D7F3CA6D7D723 CRC64;
     MTIVGLVIQQ HDGTILFQNV REYLSLDKAH LAAKAFKNQI SSYDENFITK GSISHLTGSV
     VVLNMYRVYY MILNELFILA ISQANDNPFE GSIYLARAKR VLWSVSKDFT TTQINKKYTE
     VYFALERVLF GEDGVEVLSQ KISEVSPHQP PHYNTHHHTS TPSVAPSFIT GGSTTPPPIT
     IFGRLIEPNQ SNSLSNSISN SNSNNNNNNN NDSININSIN SNIYQTTVPL TLSNVLNSSN
     FNNNNNNNNN NNNNNNNSNN SLNNSNSNSN IISPSSSSGN LSSFNNNNNN EEYNNYNNNY
     NSLDNSYSLQ FESLMRLEQS NIPEKIFTQP NTLPKIDKHI YDPPQTIKWG NPSVSHIGSS
     ASSTRVTNRI MFTLRHPNAG KEAKEKEKEK ENEFKEQQEI NNMNNNNNGA NGNSGGSGNV
     IIGSAAAGSA SSKSSPSTSP LSSSYNPSSP ETSENSFSAT PISDSNSLKN SIDNNNNNNN
     NNNNNNNSGD TPETPKRKFS LSMGTFNNSK SSLSTSNSNI STPDNGASSP LASSTSGSAS
     SAAAPPPVPL TNSAKTKMNF LNF