TSTD2_MOUSE
ID TSTD2_MOUSE Reviewed; 495 AA.
AC Q3U269; B1AWH0; Q6PES9; Q8C1D7;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2;
GN Name=Tstd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK028258; BAC25846.1; -; mRNA.
DR EMBL; AK155456; BAE33273.1; -; mRNA.
DR EMBL; AL732615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057893; AAH57893.1; -; mRNA.
DR CCDS; CCDS38757.1; -.
DR RefSeq; NP_766621.3; NM_173033.3.
DR RefSeq; XP_006538023.1; XM_006537960.2.
DR RefSeq; XP_006538024.1; XM_006537961.3.
DR RefSeq; XP_006538025.1; XM_006537962.3.
DR RefSeq; XP_006538026.1; XM_006537963.3.
DR RefSeq; XP_006538027.1; XM_006537964.2.
DR RefSeq; XP_006538028.1; XM_006537965.3.
DR AlphaFoldDB; Q3U269; -.
DR SMR; Q3U269; -.
DR BioGRID; 234861; 1.
DR STRING; 10090.ENSMUSP00000103401; -.
DR iPTMnet; Q3U269; -.
DR PhosphoSitePlus; Q3U269; -.
DR EPD; Q3U269; -.
DR MaxQB; Q3U269; -.
DR PaxDb; Q3U269; -.
DR PRIDE; Q3U269; -.
DR ProteomicsDB; 298152; -.
DR Antibodypedia; 14352; 28 antibodies from 9 providers.
DR DNASU; 272027; -.
DR Ensembl; ENSMUST00000107770; ENSMUSP00000103399; ENSMUSG00000035495.
DR Ensembl; ENSMUST00000107772; ENSMUSP00000103401; ENSMUSG00000035495.
DR GeneID; 272027; -.
DR KEGG; mmu:272027; -.
DR UCSC; uc008stg.2; mouse.
DR CTD; 158427; -.
DR MGI; MGI:3039624; Tstd2.
DR VEuPathDB; HostDB:ENSMUSG00000035495; -.
DR eggNOG; ENOG502QSQK; Eukaryota.
DR GeneTree; ENSGT00390000016307; -.
DR HOGENOM; CLU_038878_1_0_1; -.
DR InParanoid; Q3U269; -.
DR OMA; ECKEKLW; -.
DR OrthoDB; 1276106at2759; -.
DR PhylomeDB; Q3U269; -.
DR TreeFam; TF324329; -.
DR BioGRID-ORCS; 272027; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Tstd2; mouse.
DR PRO; PR:Q3U269; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3U269; protein.
DR Bgee; ENSMUSG00000035495; Expressed in optic fissure and 242 other tissues.
DR ExpressionAtlas; Q3U269; baseline and differential.
DR Genevisible; Q3U269; MM.
DR Gene3D; 3.40.250.10; -; 1.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR022111; Rhodanese_C.
DR InterPro; IPR020936; TrhO.
DR InterPro; IPR040503; TRHO_N.
DR PANTHER; PTHR43268; PTHR43268; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF12368; Rhodanese_C; 1.
DR Pfam; PF17773; UPF0176_N; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52821; SSF52821; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..495
FT /note="Thiosulfate sulfurtransferase/rhodanese-like domain-
FT containing protein 2"
FT /id="PRO_0000230674"
FT DOMAIN 300..395
FT /note="Rhodanese"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT ACT_SITE 354
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7W7"
FT CONFLICT 59
FT /note="L -> I (in Ref. 3; AAH57893)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="K -> T (in Ref. 1; BAC25846)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="N -> D (in Ref. 3; AAH57893)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 55386 MW; 2410012C50A96233 CRC64;
MPSSTSPDEE DGLETCVLKV FDLDLKESNL VNPSNSLKAE LDGSTKKKYS FAKKKAFALL
VKTKQVPAPS YEFKGKRWRC CQQLFADQIS IHRHVATQHA EDVYQQTASL LKQLTAALSA
SQSLTPTDKR SSPKDCLTPS QEVSAWLPDV SHVSPQELRS GQGDEEGEVL LYYCYCDLED
PHWVCAWQTA LCHHLHLTGK IRIATEGING TVGGSKVATR LYVEVMLSCP LFKDYLSEDD
FKSSKGGSHC FPELRVGVFE EIVPMGISPS QVSYKKPGIH LSPGEFHKEI EKLLSQSSEE
QGNTIILDCR NFYESKIGRF QGCLAPDIRK FSYFPSYVDK NLDIFRQKRV LMYCTGGIRC
ERGSAYLRAK GVCKEVFQLK GGIHKYLEEF PDGFYKGKLF VFDERFALAY NSSVVSECSY
CGAPWDQYKL CSTPQCRQLV LTCSACQGQG FTACCVTCQD KGGKQASGPS QDSFKEECEC
TARRPRIPQE QQAQS
