ID   TSTD3_HUMAN             Reviewed;          97 AA.
AC   H0UI37;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3;
DE   AltName: Full=Rhodanese domain-containing protein 3;
GN   Name=TSTD3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AL137784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48463.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48464.1; -; Genomic_DNA.
DR   EMBL; BC047952; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS83109.1; -.
DR   RefSeq; NP_001182060.1; NM_001195131.1.
DR   RefSeq; XP_016865630.1; XM_017010141.1.
DR   AlphaFoldDB; H0UI37; -.
DR   SMR; H0UI37; -.
DR   iPTMnet; H0UI37; -.
DR   PhosphoSitePlus; H0UI37; -.
DR   BioMuta; TSTD3; -.
DR   PRIDE; H0UI37; -.
DR   Antibodypedia; 81155; 5 antibodies from 1 providers.
DR   DNASU; 100130890; -.
DR   Ensembl; ENST00000452647.3; ENSP00000489733.1; ENSG00000279170.3.
DR   GeneID; 100130890; -.
DR   KEGG; hsa:100130890; -.
DR   MANE-Select; ENST00000452647.3; ENSP00000489733.1; NM_001195131.2; NP_001182060.1.
DR   CTD; 100130890; -.
DR   DisGeNET; 100130890; -.
DR   GeneCards; TSTD3; -.
DR   HGNC; HGNC:40910; TSTD3.
DR   HPA; ENSG00000279170; Low tissue specificity.
DR   MalaCards; TSTD3; -.
DR   neXtProt; NX_H0UI37; -.
DR   VEuPathDB; HostDB:ENSG00000279170; -.
DR   GeneTree; ENSGT00940000164932; -.
DR   InParanoid; H0UI37; -.
DR   PathwayCommons; H0UI37; -.
DR   BioGRID-ORCS; 100130890; 4 hits in 162 CRISPR screens.
DR   ChiTaRS; TSTD3; human.
DR   GenomeRNAi; 100130890; -.
DR   Pharos; H0UI37; Tdark.
DR   PRO; PR:H0UI37; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; H0UI37; protein.
DR   Bgee; ENSG00000279170; Expressed in calcaneal tendon and 93 other tissues.
DR   ExpressionAtlas; H0UI37; baseline and differential.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   Pfam; PF00581; Rhodanese; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..97
FT                   /note="Thiosulfate sulfurtransferase/rhodanese-like domain-
FT                   containing protein 3"
FT                   /id="PRO_0000419460"
FT   DOMAIN          32..84
FT                   /note="Rhodanese"
FT   MOD_RES         84
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D0B5"
SQ   SEQUENCE   97 AA;  11268 MW;  9BC574B142222B09 CRC64;
     MKIEKCGWSE GLTSIKGNCH NFYTAISKDV TYKELKNLLN SKNIMLIDVR EIWEILEYQK
     IPESINVPLD EVGEALQMNP RDFKEKYNEV KPSKSDS