ID   TSTE_DICDI              Reviewed;        1340 AA.
AC   Q54YB3;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=TSET complex member tstE {ECO:0000305};
DE   AltName: Full=Protein TTRAY1 {ECO:0000303|PubMed:24867644};
GN   Name=tstE {ECO:0000303|PubMed:24867644};
GN   ORFNames=DDB0218088 {ECO:0000312|EMBL:EAL68503.1};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION IN THE TSET COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=24867644; DOI=10.7554/elife.02866;
RA   Hirst J., Schlacht A., Norcott J.P., Traynor D., Bloomfield G.,
RA   Antrobus R., Kay R.R., Dacks J.B., Robinson M.S.;
RT   "Characterization of TSET, an ancient and widespread membrane trafficking
RT   complex.";
RL   Elife 3:E02866-E02866(2014).
CC   -!- SUBUNIT: Component of the TSET complex, a heterohexamer composed of
CC       tstA, tstB, tstC, tstD, tstE and tstF, which may act in plasma membrane
CC       turnover. tstA, tstB, tstC and tstD are likely to be the core complex
CC       members with tstE and tstF acting as associated scaffold proteins.
CC       {ECO:0000269|PubMed:24867644}.
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DR   EMBL; AAFI01000052; EAL68503.1; -; Genomic_DNA.
DR   RefSeq; XP_642289.1; XM_637197.1.
DR   AlphaFoldDB; Q54YB3; -.
DR   SMR; Q54YB3; -.
DR   STRING; 44689.DDB0233463; -.
DR   PaxDb; Q54YB3; -.
DR   GeneID; 8621496; -.
DR   KEGG; ddi:DDB_G0278661; -.
DR   dictyBase; DDB_G0278661; tstE.
DR   eggNOG; ENOG502RF6X; Eukaryota.
DR   HOGENOM; CLU_258448_0_0_1; -.
DR   InParanoid; Q54YB3; -.
DR   OMA; RECMNAG; -.
DR   PRO; PR:Q54YB3; -.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; IBA:GO_Central.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Repeat; WD repeat.
FT   CHAIN           1..1340
FT                   /note="TSET complex member tstE"
FT                   /id="PRO_0000445762"
FT   REPEAT          208..246
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          250..294
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          345..384
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          397..436
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REGION          56..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1216..1340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1216..1248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1253..1271
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1286..1340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1340 AA;  147664 MW;  DF22C23C2AD1E412 CRC64;
     MLKIGICSSI TISNSISNSY HSPSTSTVVV GNQLQQQQQQ QQYVQQQLQY QYDSLNQSQT
     SPNSNDGNIG GGSGGGNNAG SNIGIGGGGG GNNNNIGGGG GSGGGVNIGS GSGGGGSGSN
     SNIGGGGGGG QLGMNGMNGS NMLLINQNIP TIKSTDSIGS TVSINSTGVS LQYNSLSSTI
     GSPSSLSLLS PIISNPFSST LPNQSYMVNQ ILFNCLCFHP KSPILYAAIR NEVHFYDIIT
     KSVIGKLFID PTETIRHLIT LPGNSIQTPT FLLAFTQEGV IYLWDPETHK LQTIVHQLKL
     DDKRPITCKS AAPNKPVIFF SKNESKDIVV VDFHNKGSSP FKLKGHKKPI SAIAHHPAKT
     ILASCSTDGQ LKIWDTRNNM SFLNFEEFSS YENTRNIEHS NHYFLVFEPT GKYLVMTGSS
     GLTLVYGDLT SQNPQEVIAN GFICKGQNIL SIVHHPQLPL FFVLSIGPSG YEELSSWEIN
     NQYKTIVQSP LIPTFIPEIN DSLSYLSKYS KPLTIPKFNP VSIVIHPTKN YFSLQLEASS
     NISSTISPYP SNINSQPFSS IRHINQNIYS INSYDHLNHS FPLVSKLPLP MGFFFEPENT
     FNYPSEITFF DGTYVKSYLP LNGITKKLID TPIMVNSASG MGSGGGEDIS KGKKFLFNNE
     FQLFALIYDS FSVAAQAQLS KYLIMDLQGL VNQQGDGSDC VFIGNNQQIL ILGLDGKLAK
     VATLSKQGVS SFKNFTLVPR ITSVHSTPLG GNKVVLYFCQ EKSCLVFSKN VNQSDPSCKD
     NYMVDIDGDN GILQLQPNEK VFQIEWQSDP KSSQHICAIL TNQRIIITNS RLRIINQIHS
     PPNHHQSTSS YFQSIFWLEW TLLYTTSTHL MYMTLQNNQA PKPISTLSIS PIILSTILPD
     RMIFGYQGLQ VPGKNETTVR CQAIGILECL IIGLLSLPPF IQYEKKYLSS CLQNIVQKLD
     YTRISKHVLD KLRERSFTDL AYSLSNDMKI SQSKQSSLEK FRMAWISKQY EAANRHLSIE
     FNRISIIKNP NDTEKRQFNK LKENMRDFGR ECMNAGHYLL AKDCFQKLSE HIYLLQISIL
     LNDRDSVIAI KRDAELRGDD HVLLAACDKY LNKQNKSINK VNPPVVKILP WDPTATTNVS
     MKSGLDYLSP INLNSIQRYY PISLPFSGAS ASLNGGKHKL LRPPEESWPP EDFKHSVAIT
     PPRTLMSLVA NRLSTKSHMS STTTLRRSPS IENIRTTSTT FDSSKFNTDN QELFDDDSDD
     DSDSGADADV DSENEEDRKL VMTVPASLQH NDNSSLTNIT VTDNDSNLDQ DITSNTGSDI
     ADLNDTQLSS TPTPTTTLSS