ID   TSTF_DICDI              Reviewed;        1122 AA.
AC   Q54K14;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=TSET complex member tstF {ECO:0000305};
DE   AltName: Full=Protein TTRAY2 {ECO:0000303|PubMed:24867644};
GN   Name=tstF {ECO:0000303|PubMed:24867644};
GN   ORFNames=DDB0219262 {ECO:0000312|EMBL:EAL63648.1};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION IN THE TSET COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=24867644; DOI=10.7554/elife.02866;
RA   Hirst J., Schlacht A., Norcott J.P., Traynor D., Bloomfield G.,
RA   Antrobus R., Kay R.R., Dacks J.B., Robinson M.S.;
RT   "Characterization of TSET, an ancient and widespread membrane trafficking
RT   complex.";
RL   Elife 3:E02866-E02866(2014).
CC   -!- SUBUNIT: Component of the TSET complex, a heterohexamer composed of
CC       tstA, tstB, tstC, tstD, tstE and tstF, which may act in plasma membrane
CC       turnover. tstA, tstB, tstC and tstD are likely to be the core complex
CC       members with tstE and tstF acting as associated scaffold proteins.
CC       {ECO:0000269|PubMed:24867644}.
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DR   EMBL; AAFI01000156; EAL63648.1; -; Genomic_DNA.
DR   RefSeq; XP_637150.1; XM_632058.1.
DR   AlphaFoldDB; Q54K14; -.
DR   STRING; 44689.DDB0219262; -.
DR   PaxDb; Q54K14; -.
DR   GeneID; 8626245; -.
DR   KEGG; ddi:DDB_G0287679; -.
DR   dictyBase; DDB_G0287679; tstF.
DR   eggNOG; KOG0267; Eukaryota.
DR   HOGENOM; CLU_280255_0_0_1; -.
DR   InParanoid; Q54K14; -.
DR   OMA; YHYLMAK; -.
DR   PhylomeDB; Q54K14; -.
DR   PRO; PR:Q54K14; -.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Repeat; WD repeat.
FT   CHAIN           1..1122
FT                   /note="TSET complex member tstF"
FT                   /id="PRO_0000445763"
FT   REPEAT          298..337
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          342..381
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          383..422
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REGION          88..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1122 AA;  124475 MW;  5D6DCAF158ADA62D CRC64;
     MSSTSNENIS SYVIFKSKGQ HINTSYNPID IHPIHPWIVY ADSDSNIVIQ NYQNNEKILN
     FSISQHDEEK KEQILLLQKK VPTLSALSSS ASGINGTNNN NSGSNSSNNN NNNNGSLSNS
     PNNNNNVAFI GSTGGVDSRS ASVTSIGSGG GVVTPINVNS NSNSNSPSVP TLHVIGNQTL
     HNRSPNNTIK LSPNSSNNDS LNNNNNNINN NSTNSNNYLN ENLDKMKLGQ IKFIYFYDKH
     TRSCKDKKPK ISQNKLQNIS KAQPSVGIED YIVVVAENRI VFINYHSQRL REVKIPAFEN
     KSPNSVEFFS NSPFVAFGGP DSMIRLWNTE KWEIEKQLAG HPKGTIVKLK AIEIEGEFLV
     SGGTDGFVCV WNVKTGSLAT QFSKVHEIVD LSYDYVTGQV MALTQDRHIM IYDLNTLKEV
     SKVSCGKKEF FSIEAYYHSR FNQDLLLGMK QPAQVSFFSR SGSTKEYSID LDALLNPSKK
     EKSKLYKVVQ HPLQPHLLLC WLNKSVYIVS TLATSIPMQV TTFNSLSNDH TVYYPFAGYL
     YSSSLTNVLT CEKVQTPIQL SLNENYKLDI SPSGKYLSIH AISSGNYQIL EISTWKILEK
     GQALDVAWSG KGKDSTVDEK FGKLEKILES VDSVKKKKTL GILPSIVKST KKEETVISKI
     LLKTKEFNNN NVVQELLLHA NEDRISGGLM LGVYHKESTN SNGTLNYGSG GSIGSGSGSG
     TISSGSSNLI NGSVGGSSSN NSANSNNSNN NNNNNNNNSN NSNNNNNSSQ PILEPPIITT
     GEETESKSFQ LLDWWTLQPV GESLPPPLKI YWDQNQTHCA IAFTHYFFVF KLRPTFHMLC
     RWSLGITSAV WHNNTLFFST HNDIQCIFPH KHESSPIILA SSTGNVFPED LYDLSSGSLS
     TSKPNQSFST LPNIKPTGPI SLIEVNNEGL VLLDSNYKFY CIPLTHYLLK FFILAQMEAI
     DLAMKCSTMV DPKYHYLMAK FLTVRGHPKE CLQMNGISNF LKLQICLNNE AFETSLDIVP
     LITEAIKSGQ SITNENNNDE EVTLSSMGKM CIEIGQRAQN KNEYPTAEKA FKLATSLEPN
     SAYQELALHY VFLKKMNELK ELQQSISTTY PLESNLISLF LD