ID   TSX_ECO57               Reviewed;         294 AA.
AC   P0A928; P22786;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Nucleoside-specific channel-forming protein Tsx {ECO:0000250|UniProtKB:P0A927};
DE   Flags: Precursor;
GN   Name=tsx; OrderedLocusNames=Z0512, ECs0464;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Functions as substrate-specific channel for nucleosides and
CC       deoxynucleosides. {ECO:0000250|UniProtKB:P0A927}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P0A927}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P0A927}.
CC   -!- SIMILARITY: Belongs to the nucleoside-specific channel-forming outer
CC       membrane porin (Tsx) (TC 1.B.10) family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG54760.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33887.1; -; Genomic_DNA.
DR   PIR; H90686; H90686.
DR   RefSeq; NP_308491.1; NC_002695.1.
DR   RefSeq; WP_001295328.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0A928; -.
DR   SMR; P0A928; -.
DR   STRING; 155864.EDL933_0479; -.
DR   PRIDE; P0A928; -.
DR   EnsemblBacteria; AAG54760; AAG54760; Z0512.
DR   EnsemblBacteria; BAB33887; BAB33887; ECs_0464.
DR   GeneID; 67416514; -.
DR   GeneID; 914566; -.
DR   KEGG; ece:Z0512; -.
DR   KEGG; ecs:ECs_0464; -.
DR   PATRIC; fig|386585.9.peg.564; -.
DR   eggNOG; COG3248; Bacteria.
DR   HOGENOM; CLU_073836_0_0_6; -.
DR   OMA; KSTGWGY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.230.20; -; 1.
DR   InterPro; IPR003055; Channel_Tsx.
DR   InterPro; IPR018013; Channel_Tsx-like.
DR   InterPro; IPR036777; Channel_Tsx-like_sf.
DR   Pfam; PF03502; Channel_Tsx; 1.
DR   PRINTS; PR01277; CHANNELTSX.
DR   SUPFAM; SSF111364; SSF111364; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..294
FT                   /note="Nucleoside-specific channel-forming protein Tsx"
FT                   /id="PRO_0000025191"
SQ   SEQUENCE   294 AA;  33589 MW;  AB801DC563552A5C CRC64;
     MKKTLLAAGA VLALSSSFTV NAAENDKPQY LSDWWHQSVN VVGSYHTRFG PQIRNDTYLE
     YEAFAKKDWF DFYGYADAPV FFGGNSDAKG IWNHGSPLFM EIEPRFSIDK LTNTDLSFGP
     FKEWYFANNY IYDMGRNKDG RQSTWYMGLG TDIDTGLPMS LSMNVYAKYQ WQNYGAANEN
     EWDGYRFKIK YFVPITDLWG GQLSYIGFTN FDWGSDLGDD SGNAINGIKT RTNNSIASSH
     ILALNYDHWH YSVVARYWHD GGQWNDDAEL NFGNGNFNVR STGWGGYLVV GYNF