ID   TSX_KLEPN               Reviewed;         294 AA.
AC   P40786;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Nucleoside-specific channel-forming protein Tsx {ECO:0000305};
DE   Flags: Precursor;
GN   Name=tsx {ECO:0000303|PubMed:9043137};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=1033-5P14 / KAY2026;
RX   PubMed=9043137; DOI=10.1099/00221287-143-2-603;
RA   Nieweg A., Bremer E.;
RT   "The nucleoside-specific Tsx channel from the outer membrane of Salmonella
RT   typhimurium, Klebsiella pneumoniae and Enterobacter aerogenes: functional
RT   characterization and DNA sequence analysis of the tsx genes.";
RL   Microbiology 143:603-615(1997).
CC   -!- FUNCTION: Functions as substrate-specific channel for nucleosides and
CC       deoxynucleosides. Functions also in albicidin uptake and as receptor
CC       for colicin K. Is also a receptor for several Tsx-specific
CC       bacteriophages. {ECO:0000269|PubMed:9043137}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:9043137};
CC       Multi-pass membrane protein {ECO:0000305|PubMed:9043137}.
CC   -!- SIMILARITY: Belongs to the nucleoside-specific channel-forming outer
CC       membrane porin (Tsx) (TC 1.B.10) family. {ECO:0000305}.
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DR   EMBL; Z26656; CAA81397.1; -; Genomic_DNA.
DR   PIR; S49152; S49152.
DR   RefSeq; WP_002890412.1; NZ_WYAM01000013.1.
DR   AlphaFoldDB; P40786; -.
DR   SMR; P40786; -.
DR   OMA; KSTGWGY; -.
DR   OrthoDB; 914393at2; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.230.20; -; 1.
DR   InterPro; IPR003055; Channel_Tsx.
DR   InterPro; IPR018013; Channel_Tsx-like.
DR   InterPro; IPR036777; Channel_Tsx-like_sf.
DR   Pfam; PF03502; Channel_Tsx; 1.
DR   PRINTS; PR01277; CHANNELTSX.
DR   SUPFAM; SSF111364; SSF111364; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..294
FT                   /note="Nucleoside-specific channel-forming protein Tsx"
FT                   /id="PRO_0000025193"
SQ   SEQUENCE   294 AA;  33507 MW;  06D561920C5EB6DD CRC64;
     MKKTLLAAGA VVALSTTFAA GAAENDKPQY LSDWWHQSVN VVGSYHTRFG PQIRNDTYLE
     YEAFAKKDWF DFYGYIDAPV FFGGNSTAKG IWNKGSPLFM EIEPRFSIDK LTNTDLSFGP
     FKEWYFANNY IYDMGRNDSQ EQSTWYMGLG TDIDTGLPMS LSLNVYAKYQ WQNYGASNEN
     EWDGYRFKVK YFVPLTDLWG GSLSYIGFTN FDWGSDLGDD NFYDLNGKHA RTSNSIASSH
     ILALNYAHWH YSIVARYFHN GGQWADDAKL NFGDGPFSVR STGWGGYFVV GYNF