ID   TSX_SALTI               Reviewed;         287 AA.
AC   P0A262; P40776;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Nucleoside-specific channel-forming protein Tsx {ECO:0000250|UniProtKB:P0A927};
DE   Flags: Precursor;
GN   Name=tsx; OrderedLocusNames=STY0451, t2450;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Functions as substrate-specific channel for nucleosides and
CC       deoxynucleosides. {ECO:0000250|UniProtKB:P0A927}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P0A927}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P0A927}.
CC   -!- SIMILARITY: Belongs to the nucleoside-specific channel-forming outer
CC       membrane porin (Tsx) (TC 1.B.10) family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD08869.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70040.1; -; Genomic_DNA.
DR   RefSeq; NP_455008.1; NC_003198.1.
DR   RefSeq; WP_000752021.1; NZ_WSUR01000026.1.
DR   AlphaFoldDB; P0A262; -.
DR   SMR; P0A262; -.
DR   STRING; 220341.16501682; -.
DR   EnsemblBacteria; AAO70040; AAO70040; t2450.
DR   KEGG; stt:t2450; -.
DR   KEGG; sty:STY0451; -.
DR   PATRIC; fig|220341.7.peg.450; -.
DR   eggNOG; COG3248; Bacteria.
DR   HOGENOM; CLU_073836_0_0_6; -.
DR   OMA; KSTGWGY; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.230.20; -; 1.
DR   InterPro; IPR003055; Channel_Tsx.
DR   InterPro; IPR018013; Channel_Tsx-like.
DR   InterPro; IPR036777; Channel_Tsx-like_sf.
DR   Pfam; PF03502; Channel_Tsx; 1.
DR   PRINTS; PR01277; CHANNELTSX.
DR   SUPFAM; SSF111364; SSF111364; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..287
FT                   /note="Nucleoside-specific channel-forming protein Tsx"
FT                   /id="PRO_0000025194"
SQ   SEQUENCE   287 AA;  32778 MW;  B8502352777BE2AE CRC64;
     MKKTLLAVSA ALALTSSFTA NAAENDQPQY LSDWWHQSVN VVGSYHTRFS PKLNNDVYLE
     YEAFAKKDWF DFYGYIDIPK TFDWGNGNDK GIWSDGSPLF MEIEPRFSID KLTGADLSFG
     PFKEWYFANN YIYDMGDNKA SRQSTWYMGL GTDIDTGLPM GLSLNVYAKY QWQNYGASNE
     NEWDGYRFKV KYFVPITDLW GGKLSYIGFT NFDWGSDLGD DPNRTSNSIA SSHILALNYD
     HWHYSVVARY FHNGGQWQNG AKLNWGDGDF SAKSTGWGGY LVVGYNF