ID   TSX_SALTY               Reviewed;         287 AA.
AC   P0A261; P40776;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Nucleoside-specific channel-forming protein Tsx {ECO:0000305};
DE   Flags: Precursor;
GN   Name=tsx {ECO:0000303|PubMed:9043137}; OrderedLocusNames=STM0413;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=LT2;
RX   PubMed=9043137; DOI=10.1099/00221287-143-2-603;
RA   Nieweg A., Bremer E.;
RT   "The nucleoside-specific Tsx channel from the outer membrane of Salmonella
RT   typhimurium, Klebsiella pneumoniae and Enterobacter aerogenes: functional
RT   characterization and DNA sequence analysis of the tsx genes.";
RL   Microbiology 143:603-615(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Functions as substrate-specific channel for nucleosides and
CC       deoxynucleosides. Functions also in albicidin uptake and as receptor
CC       for colicin K. {ECO:0000269|PubMed:9043137}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:9043137};
CC       Multi-pass membrane protein {ECO:0000305|PubMed:9043137}.
CC   -!- SIMILARITY: Belongs to the nucleoside-specific channel-forming outer
CC       membrane porin (Tsx) (TC 1.B.10) family. {ECO:0000305}.
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DR   EMBL; Z26657; CAA81398.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19367.1; -; Genomic_DNA.
DR   PIR; S49159; S49159.
DR   RefSeq; NP_459408.1; NC_003197.2.
DR   RefSeq; WP_000752021.1; NC_003197.2.
DR   AlphaFoldDB; P0A261; -.
DR   SMR; P0A261; -.
DR   STRING; 99287.STM0413; -.
DR   PaxDb; P0A261; -.
DR   EnsemblBacteria; AAL19367; AAL19367; STM0413.
DR   GeneID; 1251932; -.
DR   KEGG; stm:STM0413; -.
DR   PATRIC; fig|99287.12.peg.440; -.
DR   HOGENOM; CLU_073836_0_0_6; -.
DR   OMA; KSTGWGY; -.
DR   PhylomeDB; P0A261; -.
DR   BioCyc; SENT99287:STM0413-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.230.20; -; 1.
DR   InterPro; IPR003055; Channel_Tsx.
DR   InterPro; IPR018013; Channel_Tsx-like.
DR   InterPro; IPR036777; Channel_Tsx-like_sf.
DR   Pfam; PF03502; Channel_Tsx; 1.
DR   PRINTS; PR01277; CHANNELTSX.
DR   SUPFAM; SSF111364; SSF111364; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..287
FT                   /note="Nucleoside-specific channel-forming protein Tsx"
FT                   /id="PRO_0000025195"
SQ   SEQUENCE   287 AA;  32778 MW;  B8502352777BE2AE CRC64;
     MKKTLLAVSA ALALTSSFTA NAAENDQPQY LSDWWHQSVN VVGSYHTRFS PKLNNDVYLE
     YEAFAKKDWF DFYGYIDIPK TFDWGNGNDK GIWSDGSPLF MEIEPRFSID KLTGADLSFG
     PFKEWYFANN YIYDMGDNKA SRQSTWYMGL GTDIDTGLPM GLSLNVYAKY QWQNYGASNE
     NEWDGYRFKV KYFVPITDLW GGKLSYIGFT NFDWGSDLGD DPNRTSNSIA SSHILALNYD
     HWHYSVVARY FHNGGQWQNG AKLNWGDGDF SAKSTGWGGY LVVGYNF